Urinary osteocalcin and other markers of bone metabolism: the effect of risedronate therapy
(2008) In Scandinavian Journal of Clinical & Laboratory Investigation 68(6). p.459-463- Abstract
- Objective. Serum osteocalcin (S-OC) is widely used as an index of bone formation. However, there is evidence that some urinary fragments of OC reflect resorption and might be useful in monitoring antiresorptive therapy. Here, we report 6-month changes in urinary midfragments of osteocalcin (U-MidOC) and other bone turnover markers in response to risedronate treatment. Material and methods. The study group comprised 19 patients with postmenopausal osteoporosis, aged 49-66 years, and receiving risedronate therapy. Fifty-four premenopausal women served as controls. Osteoporosis was diagnosed by lumbal bone mineral density (BMD). Urinary osteocalcin was measured by the U-MidOC assay for midfragments. Bone formation was assessed by S-PINP and... (More)
- Objective. Serum osteocalcin (S-OC) is widely used as an index of bone formation. However, there is evidence that some urinary fragments of OC reflect resorption and might be useful in monitoring antiresorptive therapy. Here, we report 6-month changes in urinary midfragments of osteocalcin (U-MidOC) and other bone turnover markers in response to risedronate treatment. Material and methods. The study group comprised 19 patients with postmenopausal osteoporosis, aged 49-66 years, and receiving risedronate therapy. Fifty-four premenopausal women served as controls. Osteoporosis was diagnosed by lumbal bone mineral density (BMD). Urinary osteocalcin was measured by the U-MidOC assay for midfragments. Bone formation was assessed by S-PINP and S-OC, and resorption by S-CTx-I. Results. At baseline, U-MidOC was significantly correlated only with S-OC. After the 1st month of therapy, a similar decrease was observed in the values of U-MidOC and S-CTx-I, but in formation markers S-P1NP and S-OC only after three months. The rapid decrease in U-MidOC, analogous to S-CTX-I, and the different kinetics for urinary and serum OC suggest that urinary OC midfragments are more associated with resorption than S-OC. An association was also observed between the 1-month change in U-MidOC and 12-month gain in lumbar BMD. The response in U-MidOC after only the 1st month of therapy makes it a potential marker for monitoring the effect of risedronate, presumably reflecting different aspects of bone resorption than S-CTx-I does. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1286958
- author
- Kumm, Jaanika ; Ivaska, Kaisa LU ; Rohtla, Kadri ; Vaananena, Kalervo and Tamm, Agu
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- postmenopause, osteoporosis, bone mineral density, antiresorptive therapy, bone markers
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 68
- issue
- 6
- pages
- 459 - 463
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000259600100004
- scopus:52949109136
- pmid:18609099
- ISSN
- 1502-7686
- DOI
- 10.1080/00365510701832237
- language
- English
- LU publication?
- yes
- id
- cc1834c5-b101-4980-82ca-e855ba27895b (old id 1286958)
- date added to LUP
- 2016-04-01 13:41:19
- date last changed
- 2024-03-13 16:05:51
@article{cc1834c5-b101-4980-82ca-e855ba27895b,
abstract = {{Objective. Serum osteocalcin (S-OC) is widely used as an index of bone formation. However, there is evidence that some urinary fragments of OC reflect resorption and might be useful in monitoring antiresorptive therapy. Here, we report 6-month changes in urinary midfragments of osteocalcin (U-MidOC) and other bone turnover markers in response to risedronate treatment. Material and methods. The study group comprised 19 patients with postmenopausal osteoporosis, aged 49-66 years, and receiving risedronate therapy. Fifty-four premenopausal women served as controls. Osteoporosis was diagnosed by lumbal bone mineral density (BMD). Urinary osteocalcin was measured by the U-MidOC assay for midfragments. Bone formation was assessed by S-PINP and S-OC, and resorption by S-CTx-I. Results. At baseline, U-MidOC was significantly correlated only with S-OC. After the 1st month of therapy, a similar decrease was observed in the values of U-MidOC and S-CTx-I, but in formation markers S-P1NP and S-OC only after three months. The rapid decrease in U-MidOC, analogous to S-CTX-I, and the different kinetics for urinary and serum OC suggest that urinary OC midfragments are more associated with resorption than S-OC. An association was also observed between the 1-month change in U-MidOC and 12-month gain in lumbar BMD. The response in U-MidOC after only the 1st month of therapy makes it a potential marker for monitoring the effect of risedronate, presumably reflecting different aspects of bone resorption than S-CTx-I does.}},
author = {{Kumm, Jaanika and Ivaska, Kaisa and Rohtla, Kadri and Vaananena, Kalervo and Tamm, Agu}},
issn = {{1502-7686}},
keywords = {{postmenopause; osteoporosis; bone mineral density; antiresorptive therapy; bone markers}},
language = {{eng}},
number = {{6}},
pages = {{459--463}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Urinary osteocalcin and other markers of bone metabolism: the effect of risedronate therapy}},
url = {{http://dx.doi.org/10.1080/00365510701832237}},
doi = {{10.1080/00365510701832237}},
volume = {{68}},
year = {{2008}},
}