Peripheral leucocyte count variations in rectal cancer treatment.
(2009) In European Journal of Surgical Oncology 35. p.611-616- Abstract
- AIM: Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. A link to the suppression of leucocytes after neoadjuvant radiotherapy has been suggested. This study investigates the effects of radiotherapy on peripheral leucocyte counts, complications and survival. METHOD: Patient data variables from a retrospective database (Local and National Swedish Registries) of a total of 926 consecutive patients treated for rectal cancer disease at two surgical units (1993-2004) were analysed for leucocyte counts and mortality. In all 310 patients received radiotherapy. Mean follow-up time was 2.8 years. RESULTS: There was a marked suppression of leucocytes in... (More)
- AIM: Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. A link to the suppression of leucocytes after neoadjuvant radiotherapy has been suggested. This study investigates the effects of radiotherapy on peripheral leucocyte counts, complications and survival. METHOD: Patient data variables from a retrospective database (Local and National Swedish Registries) of a total of 926 consecutive patients treated for rectal cancer disease at two surgical units (1993-2004) were analysed for leucocyte counts and mortality. In all 310 patients received radiotherapy. Mean follow-up time was 2.8 years. RESULTS: There was a marked suppression of leucocytes in the irradiated groups coupled with a reduction in leucocyte response to surgery (p<0.05) compared to non-irradiated patients. Long course radiotherapy resulted in a better postoperative leucocyte response. Irradiated patients with a low post/preoperative leucocyte ratio had higher complication rates. No association between leucocyte response and survival was seen in the irradiated group. CONCLUSIONS: Postoperative leucocytosis is impaired after neoadjuvant radiotherapy, independent of latency period to surgery. Irradiated patients with a suppression of leucocyte response had significantly higher complication rates. The true extent of survival could not be measured in radiotherapy groups due to the short median follow-up period. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1289273
- author
- Johnson, Louis Banka LU ; Adawi, Diya LU ; Sandberg, S ; Ottochian, B ; Albertsen, C ; Manjer, Jonas LU ; Zoucas, E ; Bohe, Måns LU and Jeppsson, Bengt LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Surgical Oncology
- volume
- 35
- pages
- 611 - 616
- publisher
- Elsevier
- external identifiers
-
- wos:000266869100010
- pmid:19168318
- scopus:65349096169
- pmid:19168318
- ISSN
- 1532-2157
- DOI
- 10.1016/j.ejso.2008.12.016
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)
- id
- c50fbcf6-b072-4f69-a1f7-6d7c52274878 (old id 1289273)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19168318?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:47
- date last changed
- 2025-04-04 14:45:57
@article{c50fbcf6-b072-4f69-a1f7-6d7c52274878, abstract = {{AIM: Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. A link to the suppression of leucocytes after neoadjuvant radiotherapy has been suggested. This study investigates the effects of radiotherapy on peripheral leucocyte counts, complications and survival. METHOD: Patient data variables from a retrospective database (Local and National Swedish Registries) of a total of 926 consecutive patients treated for rectal cancer disease at two surgical units (1993-2004) were analysed for leucocyte counts and mortality. In all 310 patients received radiotherapy. Mean follow-up time was 2.8 years. RESULTS: There was a marked suppression of leucocytes in the irradiated groups coupled with a reduction in leucocyte response to surgery (p<0.05) compared to non-irradiated patients. Long course radiotherapy resulted in a better postoperative leucocyte response. Irradiated patients with a low post/preoperative leucocyte ratio had higher complication rates. No association between leucocyte response and survival was seen in the irradiated group. CONCLUSIONS: Postoperative leucocytosis is impaired after neoadjuvant radiotherapy, independent of latency period to surgery. Irradiated patients with a suppression of leucocyte response had significantly higher complication rates. The true extent of survival could not be measured in radiotherapy groups due to the short median follow-up period.}}, author = {{Johnson, Louis Banka and Adawi, Diya and Sandberg, S and Ottochian, B and Albertsen, C and Manjer, Jonas and Zoucas, E and Bohe, Måns and Jeppsson, Bengt}}, issn = {{1532-2157}}, language = {{eng}}, pages = {{611--616}}, publisher = {{Elsevier}}, series = {{European Journal of Surgical Oncology}}, title = {{Peripheral leucocyte count variations in rectal cancer treatment.}}, url = {{http://dx.doi.org/10.1016/j.ejso.2008.12.016}}, doi = {{10.1016/j.ejso.2008.12.016}}, volume = {{35}}, year = {{2009}}, }