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Peripheral leucocyte count variations in rectal cancer treatment.

Johnson, Louis Banka LU ; Adawi, Diya LU ; Sandberg, S ; Ottochian, B ; Albertsen, C ; Manjer, Jonas LU ; Zoucas, E ; Bohe, Måns LU and Jeppsson, Bengt LU (2009) In European Journal of Surgical Oncology 35. p.611-616
Abstract
AIM: Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. A link to the suppression of leucocytes after neoadjuvant radiotherapy has been suggested. This study investigates the effects of radiotherapy on peripheral leucocyte counts, complications and survival. METHOD: Patient data variables from a retrospective database (Local and National Swedish Registries) of a total of 926 consecutive patients treated for rectal cancer disease at two surgical units (1993-2004) were analysed for leucocyte counts and mortality. In all 310 patients received radiotherapy. Mean follow-up time was 2.8 years. RESULTS: There was a marked suppression of leucocytes in... (More)
AIM: Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. A link to the suppression of leucocytes after neoadjuvant radiotherapy has been suggested. This study investigates the effects of radiotherapy on peripheral leucocyte counts, complications and survival. METHOD: Patient data variables from a retrospective database (Local and National Swedish Registries) of a total of 926 consecutive patients treated for rectal cancer disease at two surgical units (1993-2004) were analysed for leucocyte counts and mortality. In all 310 patients received radiotherapy. Mean follow-up time was 2.8 years. RESULTS: There was a marked suppression of leucocytes in the irradiated groups coupled with a reduction in leucocyte response to surgery (p<0.05) compared to non-irradiated patients. Long course radiotherapy resulted in a better postoperative leucocyte response. Irradiated patients with a low post/preoperative leucocyte ratio had higher complication rates. No association between leucocyte response and survival was seen in the irradiated group. CONCLUSIONS: Postoperative leucocytosis is impaired after neoadjuvant radiotherapy, independent of latency period to surgery. Irradiated patients with a suppression of leucocyte response had significantly higher complication rates. The true extent of survival could not be measured in radiotherapy groups due to the short median follow-up period. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Surgical Oncology
volume
35
pages
611 - 616
publisher
Elsevier
external identifiers
  • wos:000266869100010
  • pmid:19168318
  • scopus:65349096169
  • pmid:19168318
ISSN
1532-2157
DOI
10.1016/j.ejso.2008.12.016
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200)
id
c50fbcf6-b072-4f69-a1f7-6d7c52274878 (old id 1289273)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19168318?dopt=Abstract
date added to LUP
2016-04-04 08:55:47
date last changed
2025-04-04 14:45:57
@article{c50fbcf6-b072-4f69-a1f7-6d7c52274878,
  abstract     = {{AIM: Mortality after curative surgery for rectal cancer is increased if surgery is not performed within a week of completed short course radiotherapy. A link to the suppression of leucocytes after neoadjuvant radiotherapy has been suggested. This study investigates the effects of radiotherapy on peripheral leucocyte counts, complications and survival. METHOD: Patient data variables from a retrospective database (Local and National Swedish Registries) of a total of 926 consecutive patients treated for rectal cancer disease at two surgical units (1993-2004) were analysed for leucocyte counts and mortality. In all 310 patients received radiotherapy. Mean follow-up time was 2.8 years. RESULTS: There was a marked suppression of leucocytes in the irradiated groups coupled with a reduction in leucocyte response to surgery (p&lt;0.05) compared to non-irradiated patients. Long course radiotherapy resulted in a better postoperative leucocyte response. Irradiated patients with a low post/preoperative leucocyte ratio had higher complication rates. No association between leucocyte response and survival was seen in the irradiated group. CONCLUSIONS: Postoperative leucocytosis is impaired after neoadjuvant radiotherapy, independent of latency period to surgery. Irradiated patients with a suppression of leucocyte response had significantly higher complication rates. The true extent of survival could not be measured in radiotherapy groups due to the short median follow-up period.}},
  author       = {{Johnson, Louis Banka and Adawi, Diya and Sandberg, S and Ottochian, B and Albertsen, C and Manjer, Jonas and Zoucas, E and Bohe, Måns and Jeppsson, Bengt}},
  issn         = {{1532-2157}},
  language     = {{eng}},
  pages        = {{611--616}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Surgical Oncology}},
  title        = {{Peripheral leucocyte count variations in rectal cancer treatment.}},
  url          = {{http://dx.doi.org/10.1016/j.ejso.2008.12.016}},
  doi          = {{10.1016/j.ejso.2008.12.016}},
  volume       = {{35}},
  year         = {{2009}},
}