Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?
(2009) In Cellular and Molecular Life Sciences 66. p.559-564- Abstract
- Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar,... (More)
- Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-beta HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1289559
- author
- Dahlbäck, Björn LU and Nielsen, Lars
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cellular and Molecular Life Sciences
- volume
- 66
- pages
- 559 - 564
- publisher
- Birkhäuser
- external identifiers
-
- wos:000263418300002
- pmid:19153651
- scopus:60149087438
- pmid:19153651
- ISSN
- 1420-9071
- DOI
- 10.1007/s00018-009-8764-8
- language
- English
- LU publication?
- yes
- id
- ae7a35b9-1a4d-4604-88d2-c1ba0cba6e14 (old id 1289559)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19153651?dopt=Abstract
- date added to LUP
- 2016-04-04 09:34:09
- date last changed
- 2024-01-12 15:21:00
@article{ae7a35b9-1a4d-4604-88d2-c1ba0cba6e14, abstract = {{Apolipoprotein M (apoM) is a novel apolipoprotein found mainly in high-density lipoproteins (HDL). Its function is yet to be defined. ApoM (25 kDa) has a typical lipocalin beta-barrel fold and a hydrophobic pocket. Retinoids bind apoM but with low affinity and may not be the natural ligands. ApoM retains its signal peptide, which serves as a hydrophobic anchor to the lipoproteins. This prevents apoM from being lost in the urine. Approximately 5% of HDL carries an apoM molecule. ApoM in plasma (1 muM) correlates strongly with both low-density lipoprotein (LDL) and HDL cholesterol, suggesting a link to cholesterol metabolism. However, in casecontrol studies, apoM levels in patients with coronary heart disease (CHD) and controls were similar, suggesting apoM levels not to affect the risk for CHD in humans. Experiments in transgenic mice suggested apoM to have antiatherogenic properties; possible mechanisms include increased formation of pre-beta HDL, enhanced cholesterol mobilization from foam cells, and increased antioxidant properties.}}, author = {{Dahlbäck, Björn and Nielsen, Lars}}, issn = {{1420-9071}}, language = {{eng}}, pages = {{559--564}}, publisher = {{Birkhäuser}}, series = {{Cellular and Molecular Life Sciences}}, title = {{Apolipoprotein M affecting lipid metabolism or just catching a ride with lipoproteins in the circulation?}}, url = {{https://lup.lub.lu.se/search/files/5359261/1301121.pdf}}, doi = {{10.1007/s00018-009-8764-8}}, volume = {{66}}, year = {{2009}}, }