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Trends in outcomes for very preterm infants in the southern region of Sweden over a 10-year period.

Lundqvistt, Pia LU ; Källén, Karin LU ; Hallström, Inger LU and Hellström-Westas, Lena LU (2009) In Acta paediatrica 98. p.648-653
Abstract
Abstract Aim: To investigate trends in mortality and morbidity in very preterm infants. Methods: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. Results: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08-1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69-0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04-1.17) and 1.09 (95% CI: 1.03-1.16). The duration of... (More)
Abstract Aim: To investigate trends in mortality and morbidity in very preterm infants. Methods: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. Results: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08-1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69-0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04-1.17) and 1.09 (95% CI: 1.03-1.16). The duration of mechanical ventilation increased for surviving infants <25 gestational weeks (p = 0.003), while the duration of continuous positive airway pressure (CPAP) increased for infants <28 gestational weeks (p = <0.001). There were no changes in the rates of intraventricular haemorrhages (IVH, 3-4), retinopathy of prematurity (ROP, 3-5), seizures or necrotizing enterocolitis (NEC). Conclusion: During the 10-year period changes in mortality and morbidity were most pronounced for infants with GA <28 gestational weeks. The increasing rate of sepsis was present in infants <28 gestational weeks, whereas the increase in BPD was demonstrated in the whole study population <32 gestational weeks. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta paediatrica
volume
98
pages
648 - 653
publisher
Wiley-Blackwell
external identifiers
  • wos:000263965400014
  • pmid:19133870
  • scopus:61849111857
  • pmid:19133870
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2008.01155.x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Macrophage Signalling (013212039), The Vårdal Institute (016540000), Paediatrics (Lund) (013002000), Reproductive Epidemiology/Tornblad Institute (013003000)
id
ad561542-5423-4e60-ab54-8864872e1b15 (old id 1289830)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19133870?dopt=Abstract
date added to LUP
2016-04-04 09:27:52
date last changed
2025-04-04 14:02:39
@article{ad561542-5423-4e60-ab54-8864872e1b15,
  abstract     = {{Abstract Aim: To investigate trends in mortality and morbidity in very preterm infants. Methods: Population-based perinatal register; liveborn infants 22 + 0 to 31 + 6 gestational weeks were investigated (time period 1995-2004). Time trends for mortality and common morbidities were explored using logistic regression analyses. Results: Data from 1614 liveborn infants were included. There was an increase in live born infants below 25 gestational weeks, annual odds ratio (OR) 1.15 (95% CI: 1.08-1.23) and a decrease in mortality annual OR 0.82 (95% CI: 0.69-0.98). The rates of bronchopulmonary dysplasia (BPD) and sepsis increased during the study period, annual ORs of 1.10 (95% CI: 1.04-1.17) and 1.09 (95% CI: 1.03-1.16). The duration of mechanical ventilation increased for surviving infants &lt;25 gestational weeks (p = 0.003), while the duration of continuous positive airway pressure (CPAP) increased for infants &lt;28 gestational weeks (p = &lt;0.001). There were no changes in the rates of intraventricular haemorrhages (IVH, 3-4), retinopathy of prematurity (ROP, 3-5), seizures or necrotizing enterocolitis (NEC). Conclusion: During the 10-year period changes in mortality and morbidity were most pronounced for infants with GA &lt;28 gestational weeks. The increasing rate of sepsis was present in infants &lt;28 gestational weeks, whereas the increase in BPD was demonstrated in the whole study population &lt;32 gestational weeks.}},
  author       = {{Lundqvistt, Pia and Källén, Karin and Hallström, Inger and Hellström-Westas, Lena}},
  issn         = {{1651-2227}},
  language     = {{eng}},
  pages        = {{648--653}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta paediatrica}},
  title        = {{Trends in outcomes for very preterm infants in the southern region of Sweden over a 10-year period.}},
  url          = {{http://dx.doi.org/10.1111/j.1651-2227.2008.01155.x}},
  doi          = {{10.1111/j.1651-2227.2008.01155.x}},
  volume       = {{98}},
  year         = {{2009}},
}