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There is an association between contact allergy to aluminium and persistent subcutaneous nodules in children undergoing hyposensitization therapy.

Netterlid, Eva LU ; Hindsén, Monica LU ; Björk, Jonas LU ; Ekqvist, Susanne LU ; Güner, Nuray; Henricson, Kent Ake and Bruze, Magnus LU (2009) In Contact Dermatitis 60(1). p.41-49
Abstract
BACKGROUND: The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules. OBJECTIVES: To investigate if hyposensitization therapy can induce contact allergy to aluminium and examine if there is any association between persistent subcutaneous nodules and aluminium allergy. PATIENTS/METHODS: Sixty-one children with allergic asthma and/or allergic rhinitis participated in the study of whom 37 had had hyposensitization therapy. The study consisted of a non-clinical part based on a questionnaire and a clinical part with a physical... (More)
BACKGROUND: The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules. OBJECTIVES: To investigate if hyposensitization therapy can induce contact allergy to aluminium and examine if there is any association between persistent subcutaneous nodules and aluminium allergy. PATIENTS/METHODS: Sixty-one children with allergic asthma and/or allergic rhinitis participated in the study of whom 37 had had hyposensitization therapy. The study consisted of a non-clinical part based on a questionnaire and a clinical part with a physical examination, self-assessment of itching, and patch testing. To secure an unbiased evaluation of possible reactions, the investigators were blinded. RESULTS: Contact allergy to aluminium was found in eight participants, all in the exposed group (8/37 versus 0/24, P = 0.02). Examination showed nodules on the upper arms in 13 participants, all in the group exposed to hyposensitization therapy. Nodules were over-represented in patients with contact allergy to aluminium. CONCLUSIONS: There was a statistically significant association between contact allergy to aluminium and persistent subcutaneous nodules in children who had had hyposensitization therapy. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Contact Dermatitis
volume
60
issue
1
pages
41 - 49
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000262282600005
  • pmid:19125720
  • scopus:58149260450
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2008.01474.x
language
English
LU publication?
yes
id
a9ae2ff2-2e4e-4af7-9696-2ca95f6385e2 (old id 1289916)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19125720?dopt=Abstract
date added to LUP
2009-02-03 10:26:53
date last changed
2017-12-03 03:47:14
@article{a9ae2ff2-2e4e-4af7-9696-2ca95f6385e2,
  abstract     = {BACKGROUND: The development of persistent itchy nodules at the injection site following hyposensitization therapy with aluminium-precipitated antigen extract has been described in several reports. Occasionally, contact allergy to aluminium has been reported in individuals with such nodules. OBJECTIVES: To investigate if hyposensitization therapy can induce contact allergy to aluminium and examine if there is any association between persistent subcutaneous nodules and aluminium allergy. PATIENTS/METHODS: Sixty-one children with allergic asthma and/or allergic rhinitis participated in the study of whom 37 had had hyposensitization therapy. The study consisted of a non-clinical part based on a questionnaire and a clinical part with a physical examination, self-assessment of itching, and patch testing. To secure an unbiased evaluation of possible reactions, the investigators were blinded. RESULTS: Contact allergy to aluminium was found in eight participants, all in the exposed group (8/37 versus 0/24, P = 0.02). Examination showed nodules on the upper arms in 13 participants, all in the group exposed to hyposensitization therapy. Nodules were over-represented in patients with contact allergy to aluminium. CONCLUSIONS: There was a statistically significant association between contact allergy to aluminium and persistent subcutaneous nodules in children who had had hyposensitization therapy.},
  author       = {Netterlid, Eva and Hindsén, Monica and Björk, Jonas and Ekqvist, Susanne and Güner, Nuray and Henricson, Kent Ake and Bruze, Magnus},
  issn         = {0105-1873},
  language     = {eng},
  number       = {1},
  pages        = {41--49},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {There is an association between contact allergy to aluminium and persistent subcutaneous nodules in children undergoing hyposensitization therapy.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2008.01474.x},
  volume       = {60},
  year         = {2009},
}