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Synapse density related to cerebral blood flow and symptomatology in frontal lobe degeneration and Alzheimer's disease

Liu, X; Passant, Ulla LU ; Risberg, Jarl LU ; Warkentin, Siegbert LU and Brun, Arne LU (1999) In Dementia and Geriatric Cognitive Disorders 10(Suppl 1). p.64-70
Abstract
In order to evaluate the functional significance of synaptic pathology, synaptic density was quantitated and related to clinical symptomatology and regional cerebral blood flow (rCBF) in 8 patients with frontal lobe degeneration of non-Alzheimer type (FLD) and 19 patients with Alzheimer's disease (AD). Synaptic density was measured in all layers of prefrontal and parietal cortex. The clinical picture of FLD was dominated by a frontal lobe syndrome with changes in personality and behavior, while AD was dominated by temporoparietal symptoms. This parallels the finding of frontal rCBF reductions in FLD patients and temporoparietal reductions in AD patients. Synaptic density was significantly decreased in both FLD and AD, with a regional... (More)
In order to evaluate the functional significance of synaptic pathology, synaptic density was quantitated and related to clinical symptomatology and regional cerebral blood flow (rCBF) in 8 patients with frontal lobe degeneration of non-Alzheimer type (FLD) and 19 patients with Alzheimer's disease (AD). Synaptic density was measured in all layers of prefrontal and parietal cortex. The clinical picture of FLD was dominated by a frontal lobe syndrome with changes in personality and behavior, while AD was dominated by temporoparietal symptoms. This parallels the finding of frontal rCBF reductions in FLD patients and temporoparietal reductions in AD patients. Synaptic density was significantly decreased in both FLD and AD, with a regional severity which closely correlated with that of the degeneration, symptomatology and rCBF deficit. The results suggest that synaptic pathology is a likely cause of clinical symptoms and regional metabolic decrement in dementia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
10
issue
Suppl 1
pages
64 - 70
publisher
Karger
external identifiers
  • scopus:0032772395
ISSN
1420-8008
DOI
10.1159/000051216
language
English
LU publication?
yes
id
8b2dafea-fde7-4ce0-9e45-0866ef801426 (old id 1296711)
date added to LUP
2009-07-30 14:53:03
date last changed
2017-01-01 04:39:35
@article{8b2dafea-fde7-4ce0-9e45-0866ef801426,
  abstract     = {In order to evaluate the functional significance of synaptic pathology, synaptic density was quantitated and related to clinical symptomatology and regional cerebral blood flow (rCBF) in 8 patients with frontal lobe degeneration of non-Alzheimer type (FLD) and 19 patients with Alzheimer's disease (AD). Synaptic density was measured in all layers of prefrontal and parietal cortex. The clinical picture of FLD was dominated by a frontal lobe syndrome with changes in personality and behavior, while AD was dominated by temporoparietal symptoms. This parallels the finding of frontal rCBF reductions in FLD patients and temporoparietal reductions in AD patients. Synaptic density was significantly decreased in both FLD and AD, with a regional severity which closely correlated with that of the degeneration, symptomatology and rCBF deficit. The results suggest that synaptic pathology is a likely cause of clinical symptoms and regional metabolic decrement in dementia.},
  author       = {Liu, X and Passant, Ulla and Risberg, Jarl and Warkentin, Siegbert and Brun, Arne},
  issn         = {1420-8008},
  language     = {eng},
  number       = {Suppl 1},
  pages        = {64--70},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Synapse density related to cerebral blood flow and symptomatology in frontal lobe degeneration and Alzheimer's disease},
  url          = {http://dx.doi.org/10.1159/000051216},
  volume       = {10},
  year         = {1999},
}