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CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging

Sjogren, M; Minthon, Lennart LU ; Davidsson, P; Clarberg, A; Vanderstichele, H; Vanmechelen, E; Wallin, A and Blennow, K (2000) In Journal of Neural Transmission 107(5). p.563-579
Abstract
Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all... (More)
Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all groups. The results suggest normal levels of CSF-tau and CSF-beta-amyloid(1-42) in FTD, which will aid in the clinical separation of FTD from AD. In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neural Transmission
volume
107
issue
5
pages
563 - 579
publisher
Springer
external identifiers
  • wos:000086987900006
ISSN
0300-9564
DOI
10.1007/s007020070079
language
English
LU publication?
yes
id
7e39ef77-be7c-4533-a8b8-6301fd542098 (old id 1296837)
date added to LUP
2009-07-15 15:05:00
date last changed
2016-04-16 02:50:39
@article{7e39ef77-be7c-4533-a8b8-6301fd542098,
  abstract     = {Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all groups. The results suggest normal levels of CSF-tau and CSF-beta-amyloid(1-42) in FTD, which will aid in the clinical separation of FTD from AD. In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms.},
  author       = {Sjogren, M and Minthon, Lennart and Davidsson, P and Clarberg, A and Vanderstichele, H and Vanmechelen, E and Wallin, A and Blennow, K},
  issn         = {0300-9564},
  language     = {eng},
  number       = {5},
  pages        = {563--579},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging},
  url          = {http://dx.doi.org/10.1007/s007020070079},
  volume       = {107},
  year         = {2000},
}