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Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

Bretillon, L; Siden, A; Wahlund, L O; Lutjohann, D; Minthon, Lennart LU ; Crisby, M; Hillert, J; Groth, C G; Diczfalusy, U and Bjorkhem, I (2000) In Neuroscience Letters 293(2). p.87-90
Abstract
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6-10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (-43%, P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic... (More)
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6-10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (-43%, P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke, multiple sclerosis and primary brain tumors had levels not significantly different from those of controls. The conditions leading to reduced plasma levels of 24S-hydroxycholesterol had no significant effect on plasma levels of another side-chain oxidized oxysterol, 27-hydroxycholesterol. Except for conditions characterized by very marked destruction of the central nervous system, different severe neurological diseases seem to have relatively small effects on the flux of 24S-hydroxycholesterol from the brain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience Letters
volume
293
issue
2
pages
87 - 90
publisher
Elsevier
external identifiers
  • wos:000090010400002
  • scopus:0034722108
ISSN
0304-3940
DOI
10.1016/S0304-3940(00)01466-X
language
English
LU publication?
yes
id
c802d574-4155-42b1-bf8d-c9a6f206304b (old id 1296867)
date added to LUP
2009-07-15 15:08:34
date last changed
2017-07-30 03:49:03
@article{c802d574-4155-42b1-bf8d-c9a6f206304b,
  abstract     = {The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6-10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (-43%, P&lt;0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke, multiple sclerosis and primary brain tumors had levels not significantly different from those of controls. The conditions leading to reduced plasma levels of 24S-hydroxycholesterol had no significant effect on plasma levels of another side-chain oxidized oxysterol, 27-hydroxycholesterol. Except for conditions characterized by very marked destruction of the central nervous system, different severe neurological diseases seem to have relatively small effects on the flux of 24S-hydroxycholesterol from the brain.},
  author       = {Bretillon, L and Siden, A and Wahlund, L O and Lutjohann, D and Minthon, Lennart and Crisby, M and Hillert, J and Groth, C G and Diczfalusy, U and Bjorkhem, I},
  issn         = {0304-3940},
  language     = {eng},
  number       = {2},
  pages        = {87--90},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases},
  url          = {http://dx.doi.org/10.1016/S0304-3940(00)01466-X},
  volume       = {293},
  year         = {2000},
}