Advanced

TNF gene polymorphism and its relation to intracerebral production of TNFalpha and TNFbeta in AD

Tarkowski, E; Liljeroth, A M; Nilsson, A; Ricksten, A; Davidsson, P; Minthon, Lennart LU and Blennow, K (2000) In Neurology 54(11). p.2077-2081
Abstract
OBJECTIVE: To analyze the extent of tumor necrosis factor-alpha (TNFalpha) and TNFbeta gene polymorphism in patients with AD and to relate it to intrathecal levels of these cytokines. METHODS: Analyses of TNFalpha and TNFbeta gene polymorphism were performed using PCR in 52 patients with AD and in 25 control subjects, and the levels of corresponding cytokines were analyzed using ELISA. RESULTS: Patients with AD displayed significantly higher intrathecal levels of TNFalpha, but not TNFbeta, compared with the control subjects. The levels of these cytokines did not differ significantly in patients displaying different alleles of the TNF gene. CONCLUSIONS: Results indicate that increased intrathecal production of TNFalpha in AD is... (More)
OBJECTIVE: To analyze the extent of tumor necrosis factor-alpha (TNFalpha) and TNFbeta gene polymorphism in patients with AD and to relate it to intrathecal levels of these cytokines. METHODS: Analyses of TNFalpha and TNFbeta gene polymorphism were performed using PCR in 52 patients with AD and in 25 control subjects, and the levels of corresponding cytokines were analyzed using ELISA. RESULTS: Patients with AD displayed significantly higher intrathecal levels of TNFalpha, but not TNFbeta, compared with the control subjects. The levels of these cytokines did not differ significantly in patients displaying different alleles of the TNF gene. CONCLUSIONS: Results indicate that increased intrathecal production of TNFalpha in AD is preferentially controlled by environmental stimuli rather than genetic makeup. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurology
volume
54
issue
11
pages
2077 - 2081
publisher
American Academy of Neurology
external identifiers
  • wos:000087526200010
  • scopus:0034643905
ISSN
1526-632X
language
English
LU publication?
yes
id
dd51e582-1390-45e4-a1d6-3362d463e2dc (old id 1296878)
alternative location
http://www.neurology.org/cgi/content/abstract/54/11/2077
date added to LUP
2009-07-15 15:27:50
date last changed
2017-04-02 03:58:47
@article{dd51e582-1390-45e4-a1d6-3362d463e2dc,
  abstract     = {OBJECTIVE: To analyze the extent of tumor necrosis factor-alpha (TNFalpha) and TNFbeta gene polymorphism in patients with AD and to relate it to intrathecal levels of these cytokines. METHODS: Analyses of TNFalpha and TNFbeta gene polymorphism were performed using PCR in 52 patients with AD and in 25 control subjects, and the levels of corresponding cytokines were analyzed using ELISA. RESULTS: Patients with AD displayed significantly higher intrathecal levels of TNFalpha, but not TNFbeta, compared with the control subjects. The levels of these cytokines did not differ significantly in patients displaying different alleles of the TNF gene. CONCLUSIONS: Results indicate that increased intrathecal production of TNFalpha in AD is preferentially controlled by environmental stimuli rather than genetic makeup.},
  author       = {Tarkowski, E and Liljeroth, A M and Nilsson, A and Ricksten, A and Davidsson, P and Minthon, Lennart and Blennow, K},
  issn         = {1526-632X},
  language     = {eng},
  number       = {11},
  pages        = {2077--2081},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {TNF gene polymorphism and its relation to intracerebral production of TNFalpha and TNFbeta in AD},
  volume       = {54},
  year         = {2000},
}