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Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype

Sjogren, M; Hesse, C; Basun, H; Kol, G; Thostrup, H; Kilander, L; Marcusson, J; Edman, A; Wallin, A and Karlsson, I, et al. (2001) In Journal of Neural Transmission 108(4). p.451-458
Abstract
Today, cognitive impairment can be successfully treated with acetylcholine esterase inhibitors (AChE-I) in many, but not all, patients with Alzheimer's disease (AD). To investigate the relation between tacrine treatment, inheritance of ApoE epsilon4 alleles, and rate of progression, the differences in MMSE and CIBIC scores (efficacy parameters) after 6 and 12 months of tacrine (an AChE-I) treatment were investigated in 145 AD patients. Of these, 84 were ApoE epsilon4-positive (ApoE4) and 61 were ApoE epsilon4-negative (ApoE2-3). No differences were found after 6 months of treatment, but after 12 months the CIBIC scores revealed that the ApoE4 patients had declined more than the ApoE2-3 patients (p < 0.05). No differences were found for... (More)
Today, cognitive impairment can be successfully treated with acetylcholine esterase inhibitors (AChE-I) in many, but not all, patients with Alzheimer's disease (AD). To investigate the relation between tacrine treatment, inheritance of ApoE epsilon4 alleles, and rate of progression, the differences in MMSE and CIBIC scores (efficacy parameters) after 6 and 12 months of tacrine (an AChE-I) treatment were investigated in 145 AD patients. Of these, 84 were ApoE epsilon4-positive (ApoE4) and 61 were ApoE epsilon4-negative (ApoE2-3). No differences were found after 6 months of treatment, but after 12 months the CIBIC scores revealed that the ApoE4 patients had declined more than the ApoE2-3 patients (p < 0.05). No differences were found for the last 6 months of treatment. The results primarily suggest a faster rate of decline in the ApoE4 AD compared to the ApoE2-3, but may also reflect that ApoE epsilon4 genotype inheritance is a negative predictor of treatment effect of tacrine in AD patients. (Less)
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Journal of Neural Transmission
volume
108
issue
4
pages
451 - 458
publisher
Springer
external identifiers
  • wos:000167835600007
  • scopus:0034901335
ISSN
0300-9564
DOI
10.1007/s007020170066
language
English
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yes
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ca846b64-f35f-4b97-8c9a-a13eb635ff19 (old id 1297266)
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2009-07-15 10:05:21
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2018-01-07 09:07:49
@article{ca846b64-f35f-4b97-8c9a-a13eb635ff19,
  abstract     = {Today, cognitive impairment can be successfully treated with acetylcholine esterase inhibitors (AChE-I) in many, but not all, patients with Alzheimer's disease (AD). To investigate the relation between tacrine treatment, inheritance of ApoE epsilon4 alleles, and rate of progression, the differences in MMSE and CIBIC scores (efficacy parameters) after 6 and 12 months of tacrine (an AChE-I) treatment were investigated in 145 AD patients. Of these, 84 were ApoE epsilon4-positive (ApoE4) and 61 were ApoE epsilon4-negative (ApoE2-3). No differences were found after 6 months of treatment, but after 12 months the CIBIC scores revealed that the ApoE4 patients had declined more than the ApoE2-3 patients (p &lt; 0.05). No differences were found for the last 6 months of treatment. The results primarily suggest a faster rate of decline in the ApoE4 AD compared to the ApoE2-3, but may also reflect that ApoE epsilon4 genotype inheritance is a negative predictor of treatment effect of tacrine in AD patients.},
  author       = {Sjogren, M and Hesse, C and Basun, H and Kol, G and Thostrup, H and Kilander, L and Marcusson, J and Edman, A and Wallin, A and Karlsson, I and Troell, M and Wachtmaister, G and Ekdahl, A and Olofsson, H and Sandstrom, A and Andreasen, N and Minthon, Lennart and Blennow, K},
  issn         = {0300-9564},
  language     = {eng},
  number       = {4},
  pages        = {451--458},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {Tacrine and rate of progression in Alzheimer's disease--relation to ApoE allele genotype},
  url          = {http://dx.doi.org/10.1007/s007020170066},
  volume       = {108},
  year         = {2001},
}