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Ultra short-loop feedback control of thyrotropin secretion

Prummel, Mark F; Brokken, Leon LU and Wiersinga, Wilmar M (2004) In Thyroid 14(10). p.825-829
Abstract
Evidence is accumulating that pituitary hormone secretion is not only regulated by feedback from hormones produced in the target organs (long feedback) on the pituitary and the hypothalamus (feedforward), but also by a feedback of the hypophyseal hormones at the hypothalamic (short feedback) and the pituitary (ultra-short feedback) level. Inhibition of thyrotropin (TSH) and MSH secretion by pituitary preparations by adding exogenous TSH or MSH to the medium was already observed in the 1960s, as was the phenomenon that adrenocorticotropic hormone (ACTH) injected in the hypothalamus lowered plasma corticosterone levels. These early observations have now been corroborated by the demonstration of the receptors for various pituitary hormones in... (More)
Evidence is accumulating that pituitary hormone secretion is not only regulated by feedback from hormones produced in the target organs (long feedback) on the pituitary and the hypothalamus (feedforward), but also by a feedback of the hypophyseal hormones at the hypothalamic (short feedback) and the pituitary (ultra-short feedback) level. Inhibition of thyrotropin (TSH) and MSH secretion by pituitary preparations by adding exogenous TSH or MSH to the medium was already observed in the 1960s, as was the phenomenon that adrenocorticotropic hormone (ACTH) injected in the hypothalamus lowered plasma corticosterone levels. These early observations have now been corroborated by the demonstration of the receptors for various pituitary hormones in the hypothalamus and the adenohypophysis. The thyrotropin receptor (TSHR) is found on folliculo-stellate cells in the pituitary, which are known to influence the neighboring endocrine cells. This pituitary TSR-receptor is also recognized by TSHR receptor autoantibodies, which can downregulate TSH secretion independently from thyroid hormone levels, and are therefore thought to be responsible for the frequently observed suppressed TSH levels in patients with Graves' disease who are otherwise euthyroid. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Thyroid
volume
14
issue
10
pages
825 - 829
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000225071800006
  • scopus:8444233197
ISSN
1557-9077
DOI
10.1089/thy.2004.14.825
language
English
LU publication?
no
id
443639a1-07bf-4f94-815a-f0760726c961 (old id 1297738)
date added to LUP
2009-07-13 14:31:20
date last changed
2017-11-19 04:15:36
@article{443639a1-07bf-4f94-815a-f0760726c961,
  abstract     = {Evidence is accumulating that pituitary hormone secretion is not only regulated by feedback from hormones produced in the target organs (long feedback) on the pituitary and the hypothalamus (feedforward), but also by a feedback of the hypophyseal hormones at the hypothalamic (short feedback) and the pituitary (ultra-short feedback) level. Inhibition of thyrotropin (TSH) and MSH secretion by pituitary preparations by adding exogenous TSH or MSH to the medium was already observed in the 1960s, as was the phenomenon that adrenocorticotropic hormone (ACTH) injected in the hypothalamus lowered plasma corticosterone levels. These early observations have now been corroborated by the demonstration of the receptors for various pituitary hormones in the hypothalamus and the adenohypophysis. The thyrotropin receptor (TSHR) is found on folliculo-stellate cells in the pituitary, which are known to influence the neighboring endocrine cells. This pituitary TSR-receptor is also recognized by TSHR receptor autoantibodies, which can downregulate TSH secretion independently from thyroid hormone levels, and are therefore thought to be responsible for the frequently observed suppressed TSH levels in patients with Graves' disease who are otherwise euthyroid.},
  author       = {Prummel, Mark F and Brokken, Leon and Wiersinga, Wilmar M},
  issn         = {1557-9077},
  language     = {eng},
  number       = {10},
  pages        = {825--829},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Thyroid},
  title        = {Ultra short-loop feedback control of thyrotropin secretion},
  url          = {http://dx.doi.org/10.1089/thy.2004.14.825},
  volume       = {14},
  year         = {2004},
}