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Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line

Brokken, Leon LU ; Leendertse, M; Bakker, O; Wiersinga, W M and Prummel, M F (2004) In Hormone and Metabolic Research 36. p.538-541
Abstract
Adenohypophyseal-hormone production is regulated by hypothalamic peptides and target-gland hormones. Additionally, paracrine regulation by folliculo-stellate cells within the pituitary has been suggested. We recently showed TSH receptor expression in human folliculo-stellate cells and speculated that receptors for other adenohypophyseal hormones might also be expressed by folliculo-stellate cells. Using RT-PCR, we evaluated the expression of receptors for TSH, GH, ACTH, LH, FSH and PRL in a murine folliculo-stellate cell line, TtT/GF. Transcripts of TSH receptor, GH receptor and ACTH receptor were detected in this cell line. LH receptor, FSH receptor and PRL receptor expression, however, could not be demonstrated. We conclude that the... (More)
Adenohypophyseal-hormone production is regulated by hypothalamic peptides and target-gland hormones. Additionally, paracrine regulation by folliculo-stellate cells within the pituitary has been suggested. We recently showed TSH receptor expression in human folliculo-stellate cells and speculated that receptors for other adenohypophyseal hormones might also be expressed by folliculo-stellate cells. Using RT-PCR, we evaluated the expression of receptors for TSH, GH, ACTH, LH, FSH and PRL in a murine folliculo-stellate cell line, TtT/GF. Transcripts of TSH receptor, GH receptor and ACTH receptor were detected in this cell line. LH receptor, FSH receptor and PRL receptor expression, however, could not be demonstrated. We conclude that the TtT/GF cells express some, but not all, receptors for anterior pituitary hormones. This indicates that folliculo-stellate cells might act as mediators in the paracrine regulation of at least some of the hormones secreted by the anterior pituitary. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Hormone and Metabolic Research
volume
36
pages
538 - 541
publisher
Georg Thieme Verlag
external identifiers
  • wos:000223718100005
  • scopus:4544299508
ISSN
1439-4286
DOI
10.1055/s-2004-825758
language
English
LU publication?
no
id
2b88ceb7-4641-4384-992a-89771b3de173 (old id 1297743)
date added to LUP
2009-07-13 14:36:35
date last changed
2017-01-01 06:59:21
@article{2b88ceb7-4641-4384-992a-89771b3de173,
  abstract     = {Adenohypophyseal-hormone production is regulated by hypothalamic peptides and target-gland hormones. Additionally, paracrine regulation by folliculo-stellate cells within the pituitary has been suggested. We recently showed TSH receptor expression in human folliculo-stellate cells and speculated that receptors for other adenohypophyseal hormones might also be expressed by folliculo-stellate cells. Using RT-PCR, we evaluated the expression of receptors for TSH, GH, ACTH, LH, FSH and PRL in a murine folliculo-stellate cell line, TtT/GF. Transcripts of TSH receptor, GH receptor and ACTH receptor were detected in this cell line. LH receptor, FSH receptor and PRL receptor expression, however, could not be demonstrated. We conclude that the TtT/GF cells express some, but not all, receptors for anterior pituitary hormones. This indicates that folliculo-stellate cells might act as mediators in the paracrine regulation of at least some of the hormones secreted by the anterior pituitary.},
  author       = {Brokken, Leon and Leendertse, M and Bakker, O and Wiersinga, W M and Prummel, M F},
  issn         = {1439-4286},
  language     = {eng},
  pages        = {538--541},
  publisher    = {Georg Thieme Verlag},
  series       = {Hormone and Metabolic Research},
  title        = {Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line},
  url          = {http://dx.doi.org/10.1055/s-2004-825758},
  volume       = {36},
  year         = {2004},
}