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Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery

Paulsson, Kajsa M LU (2004) In Cellular and Molecular Life Sciences1997-01-01+01:00 61(19-20). p.2446-2460
Abstract
Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components... (More)
Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular and Molecular Life Sciences1997-01-01+01:00
volume
61
issue
19-20
pages
2446 - 2460
publisher
Birkhaüser
external identifiers
  • wos:000224888600005
  • scopus:9744262548
ISSN
1420-9071
DOI
10.1007/s00018-004-4113-0
language
English
LU publication?
no
id
7ab17b0d-de93-4563-85ee-de1f9b46b367 (old id 1297828)
date added to LUP
2009-07-13 15:39:27
date last changed
2018-01-07 09:37:02
@article{7ab17b0d-de93-4563-85ee-de1f9b46b367,
  abstract     = {Major histocompatibility complex (MHC) class I molecules present antigenic peptides to CD8+ T cells, providing the basis for immune recognition of pathogen-infected cells. Peptides generated mainly by proteasomes in the cytosol are transported into the lumen of the endoplasmic reticulum by transporters associated with antigen processing (TAP). The maturation of MHC class I molecules is controlled by a number of accessory proteins and chaperones that are to a varying degree dedicated to the assembly of MHC class I. Several newly characterised proteins have been demonstrated to play important roles in this process. This review focuses on the functional relationship and evolutionary history of the antigen-processing machinery (APM) components and MHC class I itself. These are of great interest for further elucidating the origin of the immune system and understanding the mechanisms of antigen presentation and immunology in general.},
  author       = {Paulsson, Kajsa M},
  issn         = {1420-9071},
  language     = {eng},
  number       = {19-20},
  pages        = {2446--2460},
  publisher    = {Birkhaüser},
  series       = {Cellular and Molecular Life Sciences1997-01-01+01:00},
  title        = {Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery},
  url          = {http://dx.doi.org/10.1007/s00018-004-4113-0},
  volume       = {61},
  year         = {2004},
}