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Quality control of MHC class I maturation

Paulsson, Kajsa M LU and Wang, Ping (2004) In FASEB Journal 18(1). p.31-38
Abstract
Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality... (More)
Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality control of MHC class I antigen presentation includes the restriction of export of suboptimally loaded MHC class I molecules to the cell surface. In this review, we use recent studies of tapasin to examine the efficiency of TAP, the LC constitution, ER quality control of class I assembly, and peptide optimization. The concepts of MHC class I recycling and ER retention are also discussed. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
FASEB Journal
volume
18
issue
1
pages
31 - 38
publisher
The Federation of American Societies for Experimental Biology
external identifiers
  • wos:000188829300037
  • scopus:0347915638
ISSN
1530-6860
DOI
10.1096/fj.03-0846rev
language
English
LU publication?
no
id
ba4a4bbd-124a-4111-b6ac-939cc0b6e2f6 (old id 1297831)
date added to LUP
2009-07-13 15:43:44
date last changed
2017-01-01 07:08:50
@article{ba4a4bbd-124a-4111-b6ac-939cc0b6e2f6,
  abstract     = {Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality control of MHC class I antigen presentation includes the restriction of export of suboptimally loaded MHC class I molecules to the cell surface. In this review, we use recent studies of tapasin to examine the efficiency of TAP, the LC constitution, ER quality control of class I assembly, and peptide optimization. The concepts of MHC class I recycling and ER retention are also discussed.},
  author       = {Paulsson, Kajsa M and Wang, Ping},
  issn         = {1530-6860},
  language     = {eng},
  number       = {1},
  pages        = {31--38},
  publisher    = {The Federation of American Societies for Experimental Biology},
  series       = {FASEB Journal},
  title        = {Quality control of MHC class I maturation},
  url          = {http://dx.doi.org/10.1096/fj.03-0846rev},
  volume       = {18},
  year         = {2004},
}