Quality control of MHC class I maturation
(2004) In FASEB Journal 18(1). p.31-38- Abstract
- Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality... (More)
- Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality control of MHC class I antigen presentation includes the restriction of export of suboptimally loaded MHC class I molecules to the cell surface. In this review, we use recent studies of tapasin to examine the efficiency of TAP, the LC constitution, ER quality control of class I assembly, and peptide optimization. The concepts of MHC class I recycling and ER retention are also discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1297831
- author
- Paulsson, Kajsa M LU and Wang, Ping
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- FASEB Journal
- volume
- 18
- issue
- 1
- pages
- 31 - 38
- publisher
- Wiley
- external identifiers
-
- wos:000188829300037
- scopus:0347915638
- ISSN
- 1530-6860
- DOI
- 10.1096/fj.03-0846rev
- language
- English
- LU publication?
- no
- id
- ba4a4bbd-124a-4111-b6ac-939cc0b6e2f6 (old id 1297831)
- date added to LUP
- 2016-04-01 16:34:13
- date last changed
- 2023-09-04 21:12:42
@article{ba4a4bbd-124a-4111-b6ac-939cc0b6e2f6, abstract = {{Assembly of MHC class I molecules in the ER is regulated by the so-called loading complex (LC). This multiprotein complex is of definite importance for class I maturation, but its exact organization and order of assembly are not known. Evidence implies that the quality of peptides loaded onto class I molecules is controlled at multiple stages during MHC class I assembly. We recently found that tapasin, an important component of the LC, interacts with COPI-coated vesicles. Biochemical studies suggested that the tapa-sin-COPI interaction regulates the retrograde transport of immature MHC class I molecules from the Golgi network back to the ER. Also other findings now propose that in addition to the peptide-loading control, the quality control of MHC class I antigen presentation includes the restriction of export of suboptimally loaded MHC class I molecules to the cell surface. In this review, we use recent studies of tapasin to examine the efficiency of TAP, the LC constitution, ER quality control of class I assembly, and peptide optimization. The concepts of MHC class I recycling and ER retention are also discussed.}}, author = {{Paulsson, Kajsa M and Wang, Ping}}, issn = {{1530-6860}}, language = {{eng}}, number = {{1}}, pages = {{31--38}}, publisher = {{Wiley}}, series = {{FASEB Journal}}, title = {{Quality control of MHC class I maturation}}, url = {{http://dx.doi.org/10.1096/fj.03-0846rev}}, doi = {{10.1096/fj.03-0846rev}}, volume = {{18}}, year = {{2004}}, }