The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease
(2010) In Acta Neurologica Scandinavica 121(3). p.186-193- Abstract
- Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly... (More)
- Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. Conclusions - AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1547124
- author
- Wiig, E. H. ; Annas, P. ; Basun, H. ; Andreasen, N. ; Lannfelt, L. ; Zetterberg, H. ; Blennow, K. and Minthon, Lennart LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- treatment, AchEI, Alzheimer's disease, MMSE, ADAS-Cog, AQT, processing speed, longitudinal stability
- in
- Acta Neurologica Scandinavica
- volume
- 121
- issue
- 3
- pages
- 186 - 193
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000273991300007
- scopus:76249087761
- pmid:19785641
- ISSN
- 1600-0404
- DOI
- 10.1111/j.1600-0404.2009.01160.x
- language
- English
- LU publication?
- yes
- id
- 12978f8e-d8f3-4dd3-a4b4-b64dc57ecdcb (old id 1547124)
- date added to LUP
- 2016-04-01 13:40:59
- date last changed
- 2022-04-06 06:22:25
@article{12978f8e-d8f3-4dd3-a4b4-b64dc57ecdcb,
abstract = {{Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. Conclusions - AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI.}},
author = {{Wiig, E. H. and Annas, P. and Basun, H. and Andreasen, N. and Lannfelt, L. and Zetterberg, H. and Blennow, K. and Minthon, Lennart}},
issn = {{1600-0404}},
keywords = {{treatment; AchEI; Alzheimer's disease; MMSE; ADAS-Cog; AQT; processing speed; longitudinal stability}},
language = {{eng}},
number = {{3}},
pages = {{186--193}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Neurologica Scandinavica}},
title = {{The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease}},
url = {{http://dx.doi.org/10.1111/j.1600-0404.2009.01160.x}},
doi = {{10.1111/j.1600-0404.2009.01160.x}},
volume = {{121}},
year = {{2010}},
}