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The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Wiig, E. H. ; Annas, P. ; Basun, H. ; Andreasen, N. ; Lannfelt, L. ; Zetterberg, H. ; Blennow, K. and Minthon, Lennart LU (2010) In Acta Neurologica Scandinavica 121(3). p.186-193
Abstract
Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly... (More)
Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. Conclusions - AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
treatment, AchEI, Alzheimer's disease, MMSE, ADAS-Cog, AQT, processing speed, longitudinal stability
in
Acta Neurologica Scandinavica
volume
121
issue
3
pages
186 - 193
publisher
Wiley-Blackwell
external identifiers
  • wos:000273991300007
  • scopus:76249087761
  • pmid:19785641
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2009.01160.x
language
English
LU publication?
yes
id
12978f8e-d8f3-4dd3-a4b4-b64dc57ecdcb (old id 1547124)
date added to LUP
2016-04-01 13:40:59
date last changed
2025-10-14 10:58:24
@article{12978f8e-d8f3-4dd3-a4b4-b64dc57ecdcb,
  abstract     = {{Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. Conclusions - AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI.}},
  author       = {{Wiig, E. H. and Annas, P. and Basun, H. and Andreasen, N. and Lannfelt, L. and Zetterberg, H. and Blennow, K. and Minthon, Lennart}},
  issn         = {{1600-0404}},
  keywords     = {{treatment; AchEI; Alzheimer's disease; MMSE; ADAS-Cog; AQT; processing speed; longitudinal stability}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{186--193}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Neurologica Scandinavica}},
  title        = {{The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0404.2009.01160.x}},
  doi          = {{10.1111/j.1600-0404.2009.01160.x}},
  volume       = {{121}},
  year         = {{2010}},
}