The PPAR-alpha gene in Alzheimer's disease: Lack of replication of earlier association
(2009) In Neurobiology of Aging 30(4). p.666-668- Abstract
- Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1298619
- author
- Sjolander, A ; Minthon, Lennart LU ; Bogdanovic, N ; Wallin, W ; Zetterberg, H and Blennow, K
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurobiology of Aging
- volume
- 30
- issue
- 4
- pages
- 666 - 668
- publisher
- Elsevier
- external identifiers
-
- wos:000264579500022
- scopus:61649120406
- ISSN
- 1558-1497
- DOI
- 10.1016/j.neurobiolaging.2007.07.018
- language
- English
- LU publication?
- yes
- id
- 9b4ebe15-fd32-4698-9cdb-cb4e62e1c261 (old id 1298619)
- date added to LUP
- 2016-04-01 12:33:31
- date last changed
- 2025-04-04 13:53:15
@article{9b4ebe15-fd32-4698-9cdb-cb4e62e1c261, abstract = {{Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.}}, author = {{Sjolander, A and Minthon, Lennart and Bogdanovic, N and Wallin, W and Zetterberg, H and Blennow, K}}, issn = {{1558-1497}}, language = {{eng}}, number = {{4}}, pages = {{666--668}}, publisher = {{Elsevier}}, series = {{Neurobiology of Aging}}, title = {{The PPAR-alpha gene in Alzheimer's disease: Lack of replication of earlier association}}, url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2007.07.018}}, doi = {{10.1016/j.neurobiolaging.2007.07.018}}, volume = {{30}}, year = {{2009}}, }