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The PPAR-alpha gene in Alzheimer's disease: Lack of replication of earlier association

Sjolander, A; Minthon, Lennart LU ; Bogdanovic, N; Wallin, W; Zetterberg, H and Blennow, K (2009) In Neurobiology of Aging 30(4). p.666-668
Abstract
Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Aging
volume
30
issue
4
pages
666 - 668
publisher
Elsevier
external identifiers
  • wos:000264579500022
  • scopus:61649120406
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2007.07.018
language
English
LU publication?
yes
id
9b4ebe15-fd32-4698-9cdb-cb4e62e1c261 (old id 1298619)
date added to LUP
2009-07-09 13:32:04
date last changed
2017-10-01 03:57:25
@article{9b4ebe15-fd32-4698-9cdb-cb4e62e1c261,
  abstract     = {Recently, a single nucleotide polymorphism (SNP, rs1800206) in the peroxisome proliferator-activated receptor alpha (PPAR-alpha) gene has been proposed to be associated with Alzheimer's disease (AD). To verify this finding, we analyzed the PPAR-alpha SNP in 461 patients with AD and 1395 controls. In subgroups, PPAR-alpha gene data could be investigated in relation to biochemical and neuropathological markers for AD. We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD.},
  author       = {Sjolander, A and Minthon, Lennart and Bogdanovic, N and Wallin, W and Zetterberg, H and Blennow, K},
  issn         = {1558-1497},
  language     = {eng},
  number       = {4},
  pages        = {666--668},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {The PPAR-alpha gene in Alzheimer's disease: Lack of replication of earlier association},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2007.07.018},
  volume       = {30},
  year         = {2009},
}