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Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease — Learnings from brain imaging biomarkers

Heurling, Kerstin ; Johansson, Edvin LU and Leuzy, Antoine LU (2020) In International Review of Neurobiology
Abstract

Medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and Alzheimer's disease. These studies have shown that there are several similarities in the effects that these seemingly disparate diseases have on the brain, and that some of the abnormalities are reversed by metabolic interventions. This review provides an overview of the overlap between these diseases using medical imaging, focusing on glucose metabolism, mitochondrial function and lipid metabolism.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Brain metabolites, Fatty acids, Hyperglycemia, Magnetic resonance imaging, Medical imaging, Metabolism, Neuroimaging, Positron emission tomography, Spectroscopy
in
International Review of Neurobiology
publisher
Elsevier
external identifiers
  • scopus:85087791992
  • pmid:32739001
ISSN
0074-7742
DOI
10.1016/bs.irn.2020.02.011
language
English
LU publication?
yes
id
129e058b-2c74-47ec-a3d6-475a9bf02541
date added to LUP
2020-07-22 13:14:38
date last changed
2020-10-22 03:00:17
@article{129e058b-2c74-47ec-a3d6-475a9bf02541,
  abstract     = {<p>Medical imaging techniques, such as structural and functional magnetic resonance imaging and positron emission tomography, have been used to gain a better understanding of the alterations of the metabolic processes in the brain relating to type 2 diabetes melltius, insulin resistance and Alzheimer's disease. These studies have shown that there are several similarities in the effects that these seemingly disparate diseases have on the brain, and that some of the abnormalities are reversed by metabolic interventions. This review provides an overview of the overlap between these diseases using medical imaging, focusing on glucose metabolism, mitochondrial function and lipid metabolism.</p>},
  author       = {Heurling, Kerstin and Johansson, Edvin and Leuzy, Antoine},
  issn         = {0074-7742},
  language     = {eng},
  month        = {07},
  publisher    = {Elsevier},
  series       = {International Review of Neurobiology},
  title        = {Disturbances in brain energy metabolism in insulin resistance and diabetes and Alzheimer's disease — Learnings from brain imaging biomarkers},
  url          = {http://dx.doi.org/10.1016/bs.irn.2020.02.011},
  doi          = {10.1016/bs.irn.2020.02.011},
  year         = {2020},
}