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ITPP treatment of RG2 glioblastoma in a rat model

Förnvik, Karolina LU orcid ; Zolfaghari, Shaian LU orcid ; Salford, Leif G. LU and Nittby, Henrietta LU (2016) In Anticancer research 36(11). p.5751-5755
Abstract

Background: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour. Materials and Methods: A model comprising of Fischer 344 rats was chosen and RG2 cells were implanted either intracranially, or subcutaneously on the left hind leg, and the animals were treated with ITPP either intraperitoneally, intravenously or both routes combined. Overall survival was then calculated. Results: No prolonged survival was seen in animals treated with ITPP. The route of ITPP... (More)

Background: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour. Materials and Methods: A model comprising of Fischer 344 rats was chosen and RG2 cells were implanted either intracranially, or subcutaneously on the left hind leg, and the animals were treated with ITPP either intraperitoneally, intravenously or both routes combined. Overall survival was then calculated. Results: No prolonged survival was seen in animals treated with ITPP. The route of ITPP administration did not affect outcome. Conclusion: ITPP had no favourable effect upon survival in our animal model with RG2 glioblastoma tumours in Fischer 344 rats.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Angiogenesis, Glioblastoma multiforme, Hypoxia, Inositol trispyrophosphate, RG2
in
Anticancer research
volume
36
issue
11
pages
5 pages
publisher
International Institute of Cancer Research
external identifiers
  • pmid:27793896
  • wos:000388486700017
  • scopus:84994045486
ISSN
0250-7005
DOI
10.21873/anticanres.11158
language
English
LU publication?
yes
id
12f53f09-7fb2-4112-9c68-30721081f378
date added to LUP
2016-11-21 09:29:26
date last changed
2025-01-12 15:30:35
@article{12f53f09-7fb2-4112-9c68-30721081f378,
  abstract     = {{<p>Background: Inositol trispyrophosphate (ITPP) has been shown to reduce tumour growth in different animal cancer models, as well as of human U87 glioma cells grafted onto chick chorioallantoic membrane (CAM). The aim of this study was to establish whether ITPP crosses the blood-brain barrier and whether it halts the growth of RG2 glioblastoma tumour. Materials and Methods: A model comprising of Fischer 344 rats was chosen and RG2 cells were implanted either intracranially, or subcutaneously on the left hind leg, and the animals were treated with ITPP either intraperitoneally, intravenously or both routes combined. Overall survival was then calculated. Results: No prolonged survival was seen in animals treated with ITPP. The route of ITPP administration did not affect outcome. Conclusion: ITPP had no favourable effect upon survival in our animal model with RG2 glioblastoma tumours in Fischer 344 rats.</p>}},
  author       = {{Förnvik, Karolina and Zolfaghari, Shaian and Salford, Leif G. and Nittby, Henrietta}},
  issn         = {{0250-7005}},
  keywords     = {{Angiogenesis; Glioblastoma multiforme; Hypoxia; Inositol trispyrophosphate; RG2}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{5751--5755}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{ITPP treatment of RG2 glioblastoma in a rat model}},
  url          = {{http://dx.doi.org/10.21873/anticanres.11158}},
  doi          = {{10.21873/anticanres.11158}},
  volume       = {{36}},
  year         = {{2016}},
}