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Maternal human polyomavirus infection and risk of neuroblastoma in the child.

Stolt, Annika; Kjellin, Mimmi; Sasnauskas, Kestutis; Luostarinen, Tapio; Koskela, Pentti; Lehtinen, Matti and Dillner, Joakim LU (2005) In International Journal of Cancer 113(3). p.393-396
Abstract
To investigate if polyomavirus infection during pregnancy is linked to development of neuroblastoma in the child, serum samples of 115 index mothers from the pregnancy where the child eventually developed neuroblastoma were identified and matched with serum samples from 8 control mothers per index mother. The samples were tested for. specific IgG and IgM antibodies to BK and JC virus using enzyme immunoassays based on purified yeast-expressed virus-like particles (VLPs). The serum samples as well as 10 neuroblastoma cell lines were also analyzed using Real Time (TaqMan) PCR for detection and quantification of BK virus DNA. The BK virus IgG seroprevalence was similar among index mothers (80%) and control mothers (83%) [OR 0.8; 95%... (More)
To investigate if polyomavirus infection during pregnancy is linked to development of neuroblastoma in the child, serum samples of 115 index mothers from the pregnancy where the child eventually developed neuroblastoma were identified and matched with serum samples from 8 control mothers per index mother. The samples were tested for. specific IgG and IgM antibodies to BK and JC virus using enzyme immunoassays based on purified yeast-expressed virus-like particles (VLPs). The serum samples as well as 10 neuroblastoma cell lines were also analyzed using Real Time (TaqMan) PCR for detection and quantification of BK virus DNA. The BK virus IgG seroprevalence was similar among index mothers (80%) and control mothers (83%) [OR 0.8; 95% confidence interval (95% CI): 0.5-1.3]. BK virus IgM was also not associated with neuroblastoma risk (OR was OR = 0.6; 956k with CI, 0.2-1.9). Also JC virus had no association, neither for IgG (OR = 0.9; 95% CI, 0.6-1.4) nor for IgM (OR = 0.9; 95% CI, 0.4-1.9). All serum samples and all neuroblastoma cell lines were negative for BKV DNA. In summary, a comprehensive cohort using both serology and polyomavirus DNA detection found no evidence for association between BKV or JCV polyomaviruses and neuroblastoma. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BK virus, maternal infection, seroprevalence, JC virus, neuroblastoma, polyomaviruses, Real Time PCR, enzyme immunoassay, virus like particles (VLPs)
in
International Journal of Cancer
volume
113
issue
3
pages
393 - 396
publisher
John Wiley & Sons
external identifiers
  • wos:000225900600008
  • pmid:15455352
  • scopus:11144344928
ISSN
0020-7136
DOI
10.1002/ijc.20573
language
English
LU publication?
yes
id
a944ecf8-152d-44ab-8537-320d6e47054b (old id 130011)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15455352&dopt=Abstract
date added to LUP
2007-07-27 10:45:35
date last changed
2017-01-01 04:50:08
@article{a944ecf8-152d-44ab-8537-320d6e47054b,
  abstract     = {To investigate if polyomavirus infection during pregnancy is linked to development of neuroblastoma in the child, serum samples of 115 index mothers from the pregnancy where the child eventually developed neuroblastoma were identified and matched with serum samples from 8 control mothers per index mother. The samples were tested for. specific IgG and IgM antibodies to BK and JC virus using enzyme immunoassays based on purified yeast-expressed virus-like particles (VLPs). The serum samples as well as 10 neuroblastoma cell lines were also analyzed using Real Time (TaqMan) PCR for detection and quantification of BK virus DNA. The BK virus IgG seroprevalence was similar among index mothers (80%) and control mothers (83%) [OR 0.8; 95% confidence interval (95% CI): 0.5-1.3]. BK virus IgM was also not associated with neuroblastoma risk (OR was OR = 0.6; 956k with CI, 0.2-1.9). Also JC virus had no association, neither for IgG (OR = 0.9; 95% CI, 0.6-1.4) nor for IgM (OR = 0.9; 95% CI, 0.4-1.9). All serum samples and all neuroblastoma cell lines were negative for BKV DNA. In summary, a comprehensive cohort using both serology and polyomavirus DNA detection found no evidence for association between BKV or JCV polyomaviruses and neuroblastoma.},
  author       = {Stolt, Annika and Kjellin, Mimmi and Sasnauskas, Kestutis and Luostarinen, Tapio and Koskela, Pentti and Lehtinen, Matti and Dillner, Joakim},
  issn         = {0020-7136},
  keyword      = {BK virus,maternal infection,seroprevalence,JC virus,neuroblastoma,polyomaviruses,Real Time PCR,enzyme immunoassay,virus like particles (VLPs)},
  language     = {eng},
  number       = {3},
  pages        = {393--396},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Maternal human polyomavirus infection and risk of neuroblastoma in the child.},
  url          = {http://dx.doi.org/10.1002/ijc.20573},
  volume       = {113},
  year         = {2005},
}