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A prospective evaluation of the diagnostic value of video capsule endoscopy in patients initially classified as irritable bowel syndrome.

Ohlsson, Bodil LU ; Bengtsson, Mariette LU ; Nielsen, Jörgen and Toth, Ervin LU (2009) In European Journal of Internal Medicine 20(1). p.48-52
Abstract
BACKGROUND: Irritable bowel syndrome (IBS) is characterized by chronic gastrointestinal dysfunction in the absence of detectable organic disease. The recently developed technique, video capsule endoscopy (CE), has been shown to be much more sensitive than traditional enterography in detecting mucosal changes in the small intestine. This study was performed to see if any earlier, not detectable by other standard methods, mucosal changes could be found in the small intestine in patients diagnosed as having IBS. METHODS: All consecutive women who, over the past five years, had received a well-founded diagnosis of IBS at the Department of Medicine were identified. Twenty-eight women, mean age 36+/-12 years were willing to participate in the... (More)
BACKGROUND: Irritable bowel syndrome (IBS) is characterized by chronic gastrointestinal dysfunction in the absence of detectable organic disease. The recently developed technique, video capsule endoscopy (CE), has been shown to be much more sensitive than traditional enterography in detecting mucosal changes in the small intestine. This study was performed to see if any earlier, not detectable by other standard methods, mucosal changes could be found in the small intestine in patients diagnosed as having IBS. METHODS: All consecutive women who, over the past five years, had received a well-founded diagnosis of IBS at the Department of Medicine were identified. Twenty-eight women, mean age 36+/-12 years were willing to participate in the study. They underwent a CE after a pre-test with a dummy capsule. The actual IBS activity was estimated by the validated Gastrointestinal Symptom Rating Scale (GSRS) and Psychological General Well-Being (PGWB) Index questionnaires. RESULTS: The duration of the IBS symptoms was a mean of 10 years (range 3-25). Symptoms were present, according to the scores of the GSRS and the PGWB index, at the time the patients underwent the CE. In the majority, 24 of 27 IBS patients examined, no specific small intestinal lesions were seen on CE. In two patients, CE revealed multiple small intestinal lesions such as ulcerations and/or erosions, and in one patient a duodenal ulceration. CONCLUSION: In the vast majority of patients who fulfil the symptom criteria of IBS, no pathological mucosal lesions can be found by CE explaining the symptomatology. However, a subgroup of these patients may benefit from investigation by CE to reconsider the diagnosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Internal Medicine
volume
20
issue
1
pages
48 - 52
publisher
Elsevier
external identifiers
  • wos:000264733900011
  • pmid:19237092
  • scopus:60349097099
ISSN
1879-0828
DOI
10.1016/j.ejim.2008.04.018
language
English
LU publication?
yes
id
ebd6ea48-0023-479c-b864-6317dd9c261c (old id 1302273)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19237092?dopt=Abstract
date added to LUP
2009-03-03 12:38:11
date last changed
2017-07-02 04:34:51
@article{ebd6ea48-0023-479c-b864-6317dd9c261c,
  abstract     = {BACKGROUND: Irritable bowel syndrome (IBS) is characterized by chronic gastrointestinal dysfunction in the absence of detectable organic disease. The recently developed technique, video capsule endoscopy (CE), has been shown to be much more sensitive than traditional enterography in detecting mucosal changes in the small intestine. This study was performed to see if any earlier, not detectable by other standard methods, mucosal changes could be found in the small intestine in patients diagnosed as having IBS. METHODS: All consecutive women who, over the past five years, had received a well-founded diagnosis of IBS at the Department of Medicine were identified. Twenty-eight women, mean age 36+/-12 years were willing to participate in the study. They underwent a CE after a pre-test with a dummy capsule. The actual IBS activity was estimated by the validated Gastrointestinal Symptom Rating Scale (GSRS) and Psychological General Well-Being (PGWB) Index questionnaires. RESULTS: The duration of the IBS symptoms was a mean of 10 years (range 3-25). Symptoms were present, according to the scores of the GSRS and the PGWB index, at the time the patients underwent the CE. In the majority, 24 of 27 IBS patients examined, no specific small intestinal lesions were seen on CE. In two patients, CE revealed multiple small intestinal lesions such as ulcerations and/or erosions, and in one patient a duodenal ulceration. CONCLUSION: In the vast majority of patients who fulfil the symptom criteria of IBS, no pathological mucosal lesions can be found by CE explaining the symptomatology. However, a subgroup of these patients may benefit from investigation by CE to reconsider the diagnosis.},
  author       = {Ohlsson, Bodil and Bengtsson, Mariette and Nielsen, Jörgen and Toth, Ervin},
  issn         = {1879-0828},
  language     = {eng},
  number       = {1},
  pages        = {48--52},
  publisher    = {Elsevier},
  series       = {European Journal of Internal Medicine},
  title        = {A prospective evaluation of the diagnostic value of video capsule endoscopy in patients initially classified as irritable bowel syndrome.},
  url          = {http://dx.doi.org/10.1016/j.ejim.2008.04.018},
  volume       = {20},
  year         = {2009},
}