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Breast Cancer-Related Chronic Arm Lymphedema Is Associated with Excess Adipose and Muscle Tissue.

Brorson, Håkan LU ; Ohlin, Karin; Olsson, Gaby and Karlsson, Magnus LU (2009) In Lymphatic Research and Biology
Abstract
Abstract Background: Arm lymphedema is a common complication after breast cancer treatment. Although conservative treatment can be used to reduce swelling, treatment often fails, possibly due to chronic edema being transformed from lymph fluid to subcutaneous fat, a condition called nonpitting lymphedema. It is currently unknown if the excess volume is solely due to excess in fat. This study evaluated whether dual energy X-ray absorptiometry (DXA) could be used to estimate the excess fat, muscle, and bone tissue in patients with arm lymphedema. Methods and Results: Eighteen women with arm lymphedema were investigated. Measurements were converted to volume values and compared with values obtained using plethysmography (PG). Linear... (More)
Abstract Background: Arm lymphedema is a common complication after breast cancer treatment. Although conservative treatment can be used to reduce swelling, treatment often fails, possibly due to chronic edema being transformed from lymph fluid to subcutaneous fat, a condition called nonpitting lymphedema. It is currently unknown if the excess volume is solely due to excess in fat. This study evaluated whether dual energy X-ray absorptiometry (DXA) could be used to estimate the excess fat, muscle, and bone tissue in patients with arm lymphedema. Methods and Results: Eighteen women with arm lymphedema were investigated. Measurements were converted to volume values and compared with values obtained using plethysmography (PG). Linear regression equations and correlation equations were used to compare the DXA and the PG techniques in regard to total volume and excess volume in the lymphedematous arm. DXA was used to estimate excess fat, muscle, and bone volume in the lymphedematous arm. Both DXA and PG provided similar total arm volume and excess volume measurements for the lymphedematous arm. The lymphedematous arm showed 73% more fat, 47% more muscle, and 7% more bone by volume in the lymphedematous arm. Conclusions: Both excess fat and muscle volume contributed to the total excess volume in nonpitting arm lymphedema; excess soft tissue developed the first few years after breast cancer surgery. DXA can be used to identify patients with excess fat in their arms and thus unsuitable for conservative treatment and may be useful in estimating the amount of fat to remove in patients scheduled for liposuction. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Lymphatic Research and Biology
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:19231988
  • scopus:62949173627
ISSN
1539-6851
DOI
10.1089/lrb.2008.1022
language
English
LU publication?
yes
id
70b7ae13-f623-4252-8d4e-c9e854ea93ce (old id 1302340)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19231988?dopt=Abstract
date added to LUP
2009-03-09 11:12:08
date last changed
2017-10-01 04:59:34
@article{70b7ae13-f623-4252-8d4e-c9e854ea93ce,
  abstract     = {Abstract Background: Arm lymphedema is a common complication after breast cancer treatment. Although conservative treatment can be used to reduce swelling, treatment often fails, possibly due to chronic edema being transformed from lymph fluid to subcutaneous fat, a condition called nonpitting lymphedema. It is currently unknown if the excess volume is solely due to excess in fat. This study evaluated whether dual energy X-ray absorptiometry (DXA) could be used to estimate the excess fat, muscle, and bone tissue in patients with arm lymphedema. Methods and Results: Eighteen women with arm lymphedema were investigated. Measurements were converted to volume values and compared with values obtained using plethysmography (PG). Linear regression equations and correlation equations were used to compare the DXA and the PG techniques in regard to total volume and excess volume in the lymphedematous arm. DXA was used to estimate excess fat, muscle, and bone volume in the lymphedematous arm. Both DXA and PG provided similar total arm volume and excess volume measurements for the lymphedematous arm. The lymphedematous arm showed 73% more fat, 47% more muscle, and 7% more bone by volume in the lymphedematous arm. Conclusions: Both excess fat and muscle volume contributed to the total excess volume in nonpitting arm lymphedema; excess soft tissue developed the first few years after breast cancer surgery. DXA can be used to identify patients with excess fat in their arms and thus unsuitable for conservative treatment and may be useful in estimating the amount of fat to remove in patients scheduled for liposuction.},
  author       = {Brorson, Håkan and Ohlin, Karin and Olsson, Gaby and Karlsson, Magnus},
  issn         = {1539-6851},
  language     = {eng},
  month        = {02},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Lymphatic Research and Biology},
  title        = {Breast Cancer-Related Chronic Arm Lymphedema Is Associated with Excess Adipose and Muscle Tissue.},
  url          = {http://dx.doi.org/10.1089/lrb.2008.1022},
  year         = {2009},
}