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Familial risk of cancer : data for clinical counseling and cancer genetics

Hemminki, Kari LU ; Li, Xinjun LU and Czene, Kamila (2004) In International Journal of Cancer 108(1). p.14-109
Abstract

Familial risks for cancer are important for clinical counseling and understanding cancer etiology. Medically verified data on familial risks have not been available for all types of cancer. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0-to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risk in offspring by an exact proband status. The familial risks for offspring cancer were increased at 24/25 sites from concordant cancer in only the parent, at 20/21 sites from a sibling... (More)

Familial risks for cancer are important for clinical counseling and understanding cancer etiology. Medically verified data on familial risks have not been available for all types of cancer. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0-to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risk in offspring by an exact proband status. The familial risks for offspring cancer were increased at 24/25 sites from concordant cancer in only the parent, at 20/21 sites from a sibling proband and at 12/12 sites from a parent and sibling proband. The highest SIRs by parent were for Hodgkin's disease (4.88) and testicular (4.26), non-medullary thyroid (3.26), ovarian (3.15) and esophageal (3.14) cancer and for multiple myeloma (3.33). When a sibling was affected, even prostate, renal, squamous cell skin, endocrine, gastric and lung cancer and leukemia showed SIRs in excess of 3.00. The highest cumulative risks were found for familial breast (5.5%) and prostate (4.2%) cancers. We identified reliable familial risks for 24 common neoplasms, most of which lack guidelines for clinical counseling or action level. If, for example, a familial SIR of 2.2 would be use as an action level, counseling would be needed for most cancers at some diagnostic age groups. The present data provide the basis for clinical counseling.

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author
organization
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type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Aged, Child, Child, Preschool, Counseling, Female, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neoplasms/epidemiology, Risk Factors, Sweden/epidemiology
in
International Journal of Cancer
volume
108
issue
1
pages
14 - 109
publisher
John Wiley & Sons
external identifiers
  • scopus:0345256389
ISSN
0020-7136
DOI
10.1002/ijc.11478
language
English
LU publication?
yes
id
13026bd1-12cf-432c-b643-fa7816888f7a
date added to LUP
2019-01-30 11:46:29
date last changed
2019-04-10 04:19:25
@article{13026bd1-12cf-432c-b643-fa7816888f7a,
  abstract     = {<p>Familial risks for cancer are important for clinical counseling and understanding cancer etiology. Medically verified data on familial risks have not been available for all types of cancer. The nationwide Swedish Family-Cancer Database includes all Swedes born in 1932 and later (0-to 68-year-old offspring) with their parents, totaling over 10.2 million individuals. Cancer cases were retrieved from the Swedish Cancer Registry up to year 2000. Standardized incidence ratios (SIR) and 95% confidence limits (CI) were calculated for age-specific familial risk in offspring by an exact proband status. The familial risks for offspring cancer were increased at 24/25 sites from concordant cancer in only the parent, at 20/21 sites from a sibling proband and at 12/12 sites from a parent and sibling proband. The highest SIRs by parent were for Hodgkin's disease (4.88) and testicular (4.26), non-medullary thyroid (3.26), ovarian (3.15) and esophageal (3.14) cancer and for multiple myeloma (3.33). When a sibling was affected, even prostate, renal, squamous cell skin, endocrine, gastric and lung cancer and leukemia showed SIRs in excess of 3.00. The highest cumulative risks were found for familial breast (5.5%) and prostate (4.2%) cancers. We identified reliable familial risks for 24 common neoplasms, most of which lack guidelines for clinical counseling or action level. If, for example, a familial SIR of 2.2 would be use as an action level, counseling would be needed for most cancers at some diagnostic age groups. The present data provide the basis for clinical counseling.</p>},
  author       = {Hemminki, Kari and Li, Xinjun and Czene, Kamila},
  issn         = {0020-7136},
  keyword      = {Adolescent,Adult,Aged,Child,Child, Preschool,Counseling,Female,Genetic Predisposition to Disease,Humans,Infant,Infant, Newborn,Male,Middle Aged,Neoplasms/epidemiology,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {14--109},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Familial risk of cancer : data for clinical counseling and cancer genetics},
  url          = {http://dx.doi.org/10.1002/ijc.11478},
  volume       = {108},
  year         = {2004},
}