Six and 12 Weeks Treatment Response Predicts Continuation of Tumor Necrosis Factor Blockade in Rheumatoid Arthritis: An Observational Cohort Study from Southern Sweden.
(2009) In Journal of Rheumatology 36. p.517-521- Abstract
- OBJECTIVE: To investigate if treatment response predicts continuation of anti-tumor necrosis factor (TNF) treatment in patients with rheumatoid arthritis (RA). METHODS: We investigated if treatment response and/or achieving a certain activity state at 6 weeks or 3 months predicts continuation of treatment in an observational cohort of 1789 anti-TNF-naive patients with established RA disease from southern Sweden. RESULTS: Response to treatment at 6 weeks at overall/American College of Rheumatology (ACR20) or good/major level (except ACR70) significantly predicted drug continuation. Response according to all criteria sets at overall/ACR20 and at good/major/ACR70 level predicted drug continuation at 3 months, as did achieving low disease... (More)
- OBJECTIVE: To investigate if treatment response predicts continuation of anti-tumor necrosis factor (TNF) treatment in patients with rheumatoid arthritis (RA). METHODS: We investigated if treatment response and/or achieving a certain activity state at 6 weeks or 3 months predicts continuation of treatment in an observational cohort of 1789 anti-TNF-naive patients with established RA disease from southern Sweden. RESULTS: Response to treatment at 6 weeks at overall/American College of Rheumatology (ACR20) or good/major level (except ACR70) significantly predicted drug continuation. Response according to all criteria sets at overall/ACR20 and at good/major/ACR70 level predicted drug continuation at 3 months, as did achieving low disease activity at 3 months irrespective of activity index applied. Remaining in a high disease activity state predicted drug discontinuation at both timepoints and according to all criteria sets. CONCLUSION: Response criteria may be useful aids in deciding on continuation of TNF blockade in RA as early as after 6 weeks of treatment. The various criteria sets perform similarly. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1302704
- author
- Gülfe, Anders LU ; Kristensen, Lars Erik LU and Geborek, Pierre LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Rheumatology
- volume
- 36
- pages
- 517 - 521
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- wos:000263940000010
- pmid:19208596
- scopus:65649093727
- pmid:19208596
- ISSN
- 0315-162X
- DOI
- 10.3899/jrheum.080509
- language
- English
- LU publication?
- yes
- id
- 755fa693-5c56-4414-9330-bcd4dffdb6ae (old id 1302704)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19208596?dopt=Abstract
- date added to LUP
- 2016-04-04 08:43:14
- date last changed
- 2022-01-29 03:53:43
@article{755fa693-5c56-4414-9330-bcd4dffdb6ae,
abstract = {{OBJECTIVE: To investigate if treatment response predicts continuation of anti-tumor necrosis factor (TNF) treatment in patients with rheumatoid arthritis (RA). METHODS: We investigated if treatment response and/or achieving a certain activity state at 6 weeks or 3 months predicts continuation of treatment in an observational cohort of 1789 anti-TNF-naive patients with established RA disease from southern Sweden. RESULTS: Response to treatment at 6 weeks at overall/American College of Rheumatology (ACR20) or good/major level (except ACR70) significantly predicted drug continuation. Response according to all criteria sets at overall/ACR20 and at good/major/ACR70 level predicted drug continuation at 3 months, as did achieving low disease activity at 3 months irrespective of activity index applied. Remaining in a high disease activity state predicted drug discontinuation at both timepoints and according to all criteria sets. CONCLUSION: Response criteria may be useful aids in deciding on continuation of TNF blockade in RA as early as after 6 weeks of treatment. The various criteria sets perform similarly.}},
author = {{Gülfe, Anders and Kristensen, Lars Erik and Geborek, Pierre}},
issn = {{0315-162X}},
language = {{eng}},
pages = {{517--521}},
publisher = {{Journal of Rheumatology Publishing Company Limited}},
series = {{Journal of Rheumatology}},
title = {{Six and 12 Weeks Treatment Response Predicts Continuation of Tumor Necrosis Factor Blockade in Rheumatoid Arthritis: An Observational Cohort Study from Southern Sweden.}},
url = {{http://dx.doi.org/10.3899/jrheum.080509}},
doi = {{10.3899/jrheum.080509}},
volume = {{36}},
year = {{2009}},
}