Altered glucose tolerance in women with deliberate self-harm.
Westling, Sofie LU
; Ahrén, Bo
LU
; Sunnqvist, Charlotta
LU
and Träskman Bendz, Lil
LU
(2009)
In Psychoneuroendocrinology
34.
p.878-883
- Abstract
- Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly... (More)
- Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly lower p-glucose nadir (p=0.015) and unaltered glucagon levels compared to controls. There were no significant differences in insulin and C-peptide levels between patients and controls. We conclude that deliberate self-harm in women may be associated with alterations in carbohydrate metabolism in certain groups. Eating disorder is a confounding factor. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1302972
- author
- Westling, Sofie
LU
; Ahrén, Bo
LU
; Sunnqvist, Charlotta
LU
and Träskman Bendz, Lil
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Psychoneuroendocrinology
- volume
- 34
- pages
- 878 - 883
- publisher
- Elsevier
- external identifiers
-
- wos:000266398800009
- pmid:19188027
- scopus:67349222180
- pmid:19188027
- ISSN
- 1873-3360
- DOI
- 10.1016/j.psyneuen.2008.12.015
- language
- English
- LU publication?
- yes
- id
- 0865f044-574d-4a88-87bc-3947def1d23c (old id 1302972)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19188027?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:55
- date last changed
- 2022-01-29 01:44:15
@article{0865f044-574d-4a88-87bc-3947def1d23c,
abstract = {{Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly lower p-glucose nadir (p=0.015) and unaltered glucagon levels compared to controls. There were no significant differences in insulin and C-peptide levels between patients and controls. We conclude that deliberate self-harm in women may be associated with alterations in carbohydrate metabolism in certain groups. Eating disorder is a confounding factor.}},
author = {{Westling, Sofie and Ahrén, Bo and Sunnqvist, Charlotta and Träskman Bendz, Lil}},
issn = {{1873-3360}},
language = {{eng}},
pages = {{878--883}},
publisher = {{Elsevier}},
series = {{Psychoneuroendocrinology}},
title = {{Altered glucose tolerance in women with deliberate self-harm.}},
url = {{http://dx.doi.org/10.1016/j.psyneuen.2008.12.015}},
doi = {{10.1016/j.psyneuen.2008.12.015}},
volume = {{34}},
year = {{2009}},
}