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Altered glucose tolerance in women with deliberate self-harm.

Westling, Sofie LU ; Ahrén, Bo LU ; Sunnqvist, Charlotta LU and Träskman Bendz, Lil LU (2009) In Psychoneuroendocrinology 34. p.878-883
Abstract
Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly... (More)
Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly lower p-glucose nadir (p=0.015) and unaltered glucagon levels compared to controls. There were no significant differences in insulin and C-peptide levels between patients and controls. We conclude that deliberate self-harm in women may be associated with alterations in carbohydrate metabolism in certain groups. Eating disorder is a confounding factor. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Psychoneuroendocrinology
volume
34
pages
878 - 883
publisher
Elsevier
external identifiers
  • wos:000266398800009
  • pmid:19188027
  • scopus:67349222180
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2008.12.015
language
English
LU publication?
yes
id
0865f044-574d-4a88-87bc-3947def1d23c (old id 1302972)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19188027?dopt=Abstract
date added to LUP
2009-03-02 14:45:58
date last changed
2017-08-27 05:41:54
@article{0865f044-574d-4a88-87bc-3947def1d23c,
  abstract     = {Disturbances in glucose metabolism are of importance for violent behaviour in men, but studies in women are lacking. We used the 5h-oral glucose tolerance test (OGTT) in this study of 17 female psychiatric patients, selected for violent behaviour directed against themselves (deliberate self-harm) and 17 healthy controls matched for age and BMI. Following OGTT, patients had higher glucose levels at 30min (p=0.007) and increased glucagon area under the curve (p=0.011). Since a co-morbid eating disorder might affect results, we as a post-hoc analysis subgrouped the patients and found that the increased glucagon levels only were present in patients with an eating disorder. In contrast, those without an eating disorder showed a significantly lower p-glucose nadir (p=0.015) and unaltered glucagon levels compared to controls. There were no significant differences in insulin and C-peptide levels between patients and controls. We conclude that deliberate self-harm in women may be associated with alterations in carbohydrate metabolism in certain groups. Eating disorder is a confounding factor.},
  author       = {Westling, Sofie and Ahrén, Bo and Sunnqvist, Charlotta and Träskman Bendz, Lil},
  issn         = {1873-3360},
  language     = {eng},
  pages        = {878--883},
  publisher    = {Elsevier},
  series       = {Psychoneuroendocrinology},
  title        = {Altered glucose tolerance in women with deliberate self-harm.},
  url          = {http://dx.doi.org/10.1016/j.psyneuen.2008.12.015},
  volume       = {34},
  year         = {2009},
}