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Infection with Parvovirus B19 and Herpes viruses in early pregnancy and risk of second trimester miscarriage or very preterm birth

Johansson, Stefan; Buchmayer, Susanne; Harlid, Sophia LU ; Iliadou, Anastasia; Sjöholm, Malin LU ; Grillner, Lena; Norman, Mikael; Sparen, Par; Dillner, Joakim LU and Cnattingius, Sven (2008) In Reproductive Toxicology 26(3-4). p.298-302
Abstract
We investigated whether infections with Parvovirus B19 and Herpes viruses in early pregnancy increase risks of second trimester miscarriage or delivery before 32 gestational weeks. Blood samples taken in early pregnancy were analyzed for Parvovirus B19 or Herpes viruses. Viremia was found in blood samples of 11 (4.7%) women with second trimester miscarriage and 10 (3.7%)women with very preterm birth, compared to 5 (1.7%) women who delivered at term, corresponding to adjusted odds ratios [95% CI] of 3.32 [0.93, 11.8] and 2.21 [0.71, 6.84], respectively. In stratified analyses, Parvovirus B19 viremia was associated with adjusted odds ratios of 3.76 [0.77, 18.3] for second trimester miscarriage and 2.66 [0.64, 11.1] for very preterm birth.... (More)
We investigated whether infections with Parvovirus B19 and Herpes viruses in early pregnancy increase risks of second trimester miscarriage or delivery before 32 gestational weeks. Blood samples taken in early pregnancy were analyzed for Parvovirus B19 or Herpes viruses. Viremia was found in blood samples of 11 (4.7%) women with second trimester miscarriage and 10 (3.7%)women with very preterm birth, compared to 5 (1.7%) women who delivered at term, corresponding to adjusted odds ratios [95% CI] of 3.32 [0.93, 11.8] and 2.21 [0.71, 6.84], respectively. In stratified analyses, Parvovirus B19 viremia was associated with adjusted odds ratios of 3.76 [0.77, 18.3] for second trimester miscarriage and 2.66 [0.64, 11.1] for very preterm birth. Corresponding odds ratios for Human Herpes virus 6 viremia was 2.52 [0.33, 19.5] and 1.08 [0.14, 8.08], respectively. In conclusion, this study lends some support to the hypothesis that women with viremia in early pregnancy may face an increased risk of second trimester miscarriage or very preterm birth. Studies with larger sample sizes are needed. (C) 2008 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Herpesviridae, Human, Abortion, Premature birth, Spontaneous, Pregnancy, Parvovirus B19
in
Reproductive Toxicology
volume
26
issue
3-4
pages
298 - 302
publisher
Elsevier
external identifiers
  • wos:000261519100017
  • scopus:55949105491
ISSN
1873-1708
DOI
10.1016/j.reprotox.2008.09.012
language
English
LU publication?
yes
id
d19807d6-e3b7-4616-a98f-65d968150bdd (old id 1304392)
date added to LUP
2009-03-23 15:02:29
date last changed
2017-10-29 03:45:31
@article{d19807d6-e3b7-4616-a98f-65d968150bdd,
  abstract     = {We investigated whether infections with Parvovirus B19 and Herpes viruses in early pregnancy increase risks of second trimester miscarriage or delivery before 32 gestational weeks. Blood samples taken in early pregnancy were analyzed for Parvovirus B19 or Herpes viruses. Viremia was found in blood samples of 11 (4.7%) women with second trimester miscarriage and 10 (3.7%)women with very preterm birth, compared to 5 (1.7%) women who delivered at term, corresponding to adjusted odds ratios [95% CI] of 3.32 [0.93, 11.8] and 2.21 [0.71, 6.84], respectively. In stratified analyses, Parvovirus B19 viremia was associated with adjusted odds ratios of 3.76 [0.77, 18.3] for second trimester miscarriage and 2.66 [0.64, 11.1] for very preterm birth. Corresponding odds ratios for Human Herpes virus 6 viremia was 2.52 [0.33, 19.5] and 1.08 [0.14, 8.08], respectively. In conclusion, this study lends some support to the hypothesis that women with viremia in early pregnancy may face an increased risk of second trimester miscarriage or very preterm birth. Studies with larger sample sizes are needed. (C) 2008 Elsevier Inc. All rights reserved.},
  author       = {Johansson, Stefan and Buchmayer, Susanne and Harlid, Sophia and Iliadou, Anastasia and Sjöholm, Malin and Grillner, Lena and Norman, Mikael and Sparen, Par and Dillner, Joakim and Cnattingius, Sven},
  issn         = {1873-1708},
  keyword      = {Herpesviridae,Human,Abortion,Premature birth,Spontaneous,Pregnancy,Parvovirus B19},
  language     = {eng},
  number       = {3-4},
  pages        = {298--302},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Infection with Parvovirus B19 and Herpes viruses in early pregnancy and risk of second trimester miscarriage or very preterm birth},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2008.09.012},
  volume       = {26},
  year         = {2008},
}