Advanced

Telomere Length Is Associated With Obesity Parameters but With a Gender Difference

Nordfjall, Katarina; Eliasson, Mats; Stegmayr, Birgitta; Melander, Olle LU ; Nilsson, Peter LU and Roos, Goran (2008) In Obesity 16(12). p.2682-2689
Abstract
Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmo Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = -0.106, P = 0.021, weight: r = -0.087, P = 0.060, waist circumference: r = -0.099, P = 0.032, hip circumference: r = -0.128, P = 0.005). In men, a positive... (More)
Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmo Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = -0.106, P = 0.021, weight: r = -0.087, P = 0.060, waist circumference: r = -0.099, P = 0.032, hip circumference: r = -0.128, P = 0.005). In men, a positive borderline correlation to high-density lipoprotein (HDL) (r = 0.111, P = 0.053) and a negative correlation to 2-h post-oral glucose-tolerance test (OGTT) was observed (r = -0.202, P = 0.045). In neither group any association was found between telomere length and cholesterol, serum triglycerides, serum low-density lipoprotein, plasma insulin, blood pressure, pulse pressure, or smoking habits. Our data indicate that telomere length is associated with an "obesity-phenotype" but only in women. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
16
issue
12
pages
2682 - 2689
publisher
Nature Publishing Group
external identifiers
  • wos:000261405800018
  • scopus:58149303043
ISSN
1930-739X
DOI
10.1038/oby.2008.413
language
English
LU publication?
yes
id
13e6535b-a022-46da-a81e-f11479bc3c53 (old id 1305391)
date added to LUP
2009-03-23 13:44:02
date last changed
2017-08-20 03:31:19
@article{13e6535b-a022-46da-a81e-f11479bc3c53,
  abstract     = {Cardiovascular disease (CVD) and obesity have been coupled to short telomere length in peripheral blood. The biological background to this observation is not obvious from the literature. In this study we have analyzed a large set of known risk factors for CVD in relation to telomere length in blood cells on a merged cohort of 989 individuals recruited in the Malmo Diet and Cancer Cohort (MDCC) and the Northern Sweden MONICA project. We found a significant or borderline association between obesity parameters and telomere length in women after age and center adjustments (BMI: r = -0.106, P = 0.021, weight: r = -0.087, P = 0.060, waist circumference: r = -0.099, P = 0.032, hip circumference: r = -0.128, P = 0.005). In men, a positive borderline correlation to high-density lipoprotein (HDL) (r = 0.111, P = 0.053) and a negative correlation to 2-h post-oral glucose-tolerance test (OGTT) was observed (r = -0.202, P = 0.045). In neither group any association was found between telomere length and cholesterol, serum triglycerides, serum low-density lipoprotein, plasma insulin, blood pressure, pulse pressure, or smoking habits. Our data indicate that telomere length is associated with an "obesity-phenotype" but only in women.},
  author       = {Nordfjall, Katarina and Eliasson, Mats and Stegmayr, Birgitta and Melander, Olle and Nilsson, Peter and Roos, Goran},
  issn         = {1930-739X},
  language     = {eng},
  number       = {12},
  pages        = {2682--2689},
  publisher    = {Nature Publishing Group},
  series       = {Obesity},
  title        = {Telomere Length Is Associated With Obesity Parameters but With a Gender Difference},
  url          = {http://dx.doi.org/10.1038/oby.2008.413},
  volume       = {16},
  year         = {2008},
}