Advanced

Screening for pulmonary hypertension in systemic sclerosis: the longitudinal development of tricuspid gradient in 227 consecutive patients, 1992-2001.

Hesselstrand, Roger LU ; Ekman, R; Eskilsson, Jan LU ; Isaksson, Anders LU ; Scheja, Agneta LU ; Öhlin, Ann-Kristin LU and Åkesson, Anita LU (2005) In Rheumatology 44(3). p.366-371
Abstract
Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-brain natriuretic peptide (proBNP), calcitonin-gene related peptide, thrombomodulin and von Willebrand factor in 76 patients with a borderline increase in TG, defined as TG 24-38 mmHg, and for the purpose of comparison also in 10 patients with a normal TG (<23 mmHg) and in 10 patients with increased TG (TG > 38 mmHg). Results. TG >23 mmHg... (More)
Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-brain natriuretic peptide (proBNP), calcitonin-gene related peptide, thrombomodulin and von Willebrand factor in 76 patients with a borderline increase in TG, defined as TG 24-38 mmHg, and for the purpose of comparison also in 10 patients with a normal TG (<23 mmHg) and in 10 patients with increased TG (TG > 38 mmHg). Results. TG >23 mmHg was found in 102 patients (44.9%) at the first assessment point and in 139 patients (61.2%) respectively, cumulatively at follow-up. TG values >33 mmHg were measured in 24 patients (10.6%) initially and in 38 patients (16.7%) cumulatively in a subsequent assessment. Age and the presence of interstitial lung disease (ILD) were associated with more frequent occurrence of TG >23 and >33 mmHg initially and at follow-up, but were not associated with progression rate. The change in TG (mean +/- s.d.) was 1.34 +/- 4.55 mmHg/yr. ProBNP correlated to TG. Conclusion. An increased TG, indicating possible PAH, is common and progressive in SSc. Age and ILD increase the risk of increased TG. Patients with or without ILD have similar progression of TG. ProBNP has potential as an adjunct to TG in selecting patients eligible for invasive treatment. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pulmonary arterial systolic, tricuspid gradient, ProBNP, pulmonary arterial hypertension, pressure, systemic sclerosis
in
Rheumatology
volume
44
issue
3
pages
366 - 371
publisher
Oxford University Press
external identifiers
  • wos:000227241400018
  • pmid:15561735
  • scopus:14944346766
ISSN
1462-0332
DOI
10.1093/rheumatology/keh486
language
English
LU publication?
yes
id
e0109f25-240e-42ba-a395-cce3e49a309b (old id 130695)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15561735&dopt=Abstract
date added to LUP
2007-07-04 13:17:16
date last changed
2017-08-06 04:26:28
@article{e0109f25-240e-42ba-a395-cce3e49a309b,
  abstract     = {Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-brain natriuretic peptide (proBNP), calcitonin-gene related peptide, thrombomodulin and von Willebrand factor in 76 patients with a borderline increase in TG, defined as TG 24-38 mmHg, and for the purpose of comparison also in 10 patients with a normal TG (&lt;23 mmHg) and in 10 patients with increased TG (TG &gt; 38 mmHg). Results. TG &gt;23 mmHg was found in 102 patients (44.9%) at the first assessment point and in 139 patients (61.2%) respectively, cumulatively at follow-up. TG values &gt;33 mmHg were measured in 24 patients (10.6%) initially and in 38 patients (16.7%) cumulatively in a subsequent assessment. Age and the presence of interstitial lung disease (ILD) were associated with more frequent occurrence of TG &gt;23 and &gt;33 mmHg initially and at follow-up, but were not associated with progression rate. The change in TG (mean +/- s.d.) was 1.34 +/- 4.55 mmHg/yr. ProBNP correlated to TG. Conclusion. An increased TG, indicating possible PAH, is common and progressive in SSc. Age and ILD increase the risk of increased TG. Patients with or without ILD have similar progression of TG. ProBNP has potential as an adjunct to TG in selecting patients eligible for invasive treatment.},
  author       = {Hesselstrand, Roger and Ekman, R and Eskilsson, Jan and Isaksson, Anders and Scheja, Agneta and Öhlin, Ann-Kristin and Åkesson, Anita},
  issn         = {1462-0332},
  keyword      = {pulmonary arterial systolic,tricuspid gradient,ProBNP,pulmonary arterial hypertension,pressure,systemic sclerosis},
  language     = {eng},
  number       = {3},
  pages        = {366--371},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Screening for pulmonary hypertension in systemic sclerosis: the longitudinal development of tricuspid gradient in 227 consecutive patients, 1992-2001.},
  url          = {http://dx.doi.org/10.1093/rheumatology/keh486},
  volume       = {44},
  year         = {2005},
}