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Signal transduction via the stem cell factor receptor/c-Kit.

Rönnstrand, Lars LU (2004) In Cellular and Molecular Life Sciences1997-01-01+01:00 61(19-20). p.2535-2548
Abstract
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.

Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will... (More)
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.

Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cellular and Molecular Life Sciences1997-01-01+01:00
volume
61
issue
19-20
pages
2535 - 2548
publisher
Birkhaüser
external identifiers
  • wos:000224888600012
  • scopus:9744246909
ISSN
1420-9071
DOI
10.1007/s00018-004-4189-6
language
English
LU publication?
yes
id
efc8642d-c784-4124-960c-8e79d10813ad (old id 130962)
date added to LUP
2007-07-26 16:17:33
date last changed
2017-12-10 04:34:58
@article{efc8642d-c784-4124-960c-8e79d10813ad,
  abstract     = {Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.<br/><br>
Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling.},
  author       = {Rönnstrand, Lars},
  issn         = {1420-9071},
  language     = {eng},
  number       = {19-20},
  pages        = {2535--2548},
  publisher    = {Birkhaüser},
  series       = {Cellular and Molecular Life Sciences1997-01-01+01:00},
  title        = {Signal transduction via the stem cell factor receptor/c-Kit.},
  url          = {http://dx.doi.org/10.1007/s00018-004-4189-6},
  volume       = {61},
  year         = {2004},
}