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Male Circumcision and Serologically Determined Human Papillomavirus Infection in a Birth Cohort

Dickson, Nigel P.; Ryding, Janka LU ; van Roode, Thea; Paul, Charlotte; Herbison, Peter; Dillner, Joakim LU and Skegg, David C. G. (2009) In Cancer Epidemiology Biomarkers & Prevention 18(1). p.177-183
Abstract
Circumcision has been reported to protect against infection with human papillomavirus (HPV) in men, but results have been inconsistent. We followed males in a birth cohort born in Dunedin, New Zealand, in 1972 and 1973 from age 3 to 32 years. Seropositivity at age 32 years for the oncogenic types HPV-16 and 18, and the nononcogenic types 6 and 11, was studied in relation to maternal reports of circumcision status at age 3 for 450 men. Seropositivity to any of these types was associated with lifetime number of sexual partners (P = 0.03), and lower moral-religious emphasis of the family of origin (P < 0.001). Circumcision was not found to be protective, with the adjusted odds ratio (95% confidence interval) for HPV6/11/16/18... (More)
Circumcision has been reported to protect against infection with human papillomavirus (HPV) in men, but results have been inconsistent. We followed males in a birth cohort born in Dunedin, New Zealand, in 1972 and 1973 from age 3 to 32 years. Seropositivity at age 32 years for the oncogenic types HPV-16 and 18, and the nononcogenic types 6 and 11, was studied in relation to maternal reports of circumcision status at age 3 for 450 men. Seropositivity to any of these types was associated with lifetime number of sexual partners (P = 0.03), and lower moral-religious emphasis of the family of origin (P < 0.001). Circumcision was not found to be protective, with the adjusted odds ratio (95% confidence interval) for HPV6/11/16/18 seropositivity among the circumcised compared with the uncircumcised being 1.4 (0.89-2.2). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Epidemiology Biomarkers & Prevention
volume
18
issue
1
pages
177 - 183
publisher
American Association for Cancer Research
external identifiers
  • wos:000262424200023
  • scopus:58349091479
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-08-0353
language
English
LU publication?
yes
id
3e6f33c8-89ae-49a3-add4-62e2d8de646c (old id 1312859)
date added to LUP
2009-03-18 09:03:14
date last changed
2017-01-01 05:51:27
@article{3e6f33c8-89ae-49a3-add4-62e2d8de646c,
  abstract     = {Circumcision has been reported to protect against infection with human papillomavirus (HPV) in men, but results have been inconsistent. We followed males in a birth cohort born in Dunedin, New Zealand, in 1972 and 1973 from age 3 to 32 years. Seropositivity at age 32 years for the oncogenic types HPV-16 and 18, and the nononcogenic types 6 and 11, was studied in relation to maternal reports of circumcision status at age 3 for 450 men. Seropositivity to any of these types was associated with lifetime number of sexual partners (P = 0.03), and lower moral-religious emphasis of the family of origin (P &lt; 0.001). Circumcision was not found to be protective, with the adjusted odds ratio (95% confidence interval) for HPV6/11/16/18 seropositivity among the circumcised compared with the uncircumcised being 1.4 (0.89-2.2).},
  author       = {Dickson, Nigel P. and Ryding, Janka and van Roode, Thea and Paul, Charlotte and Herbison, Peter and Dillner, Joakim and Skegg, David C. G.},
  issn         = {1538-7755},
  language     = {eng},
  number       = {1},
  pages        = {177--183},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Male Circumcision and Serologically Determined Human Papillomavirus Infection in a Birth Cohort},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-08-0353},
  volume       = {18},
  year         = {2009},
}