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A pooled analysis of Melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes

Chang, Yu-mei; Newton-Bishop, Julia A.; Bishop, D. Timothy; Armstrong, Bruce K.; Bataille, Veronique; Bergman, Wilma; Berwick, Marianne; Bracci, Paige M.; Elwood, J. Mark and Ernstoff, Marc S., et al. (2009) In International Journal of Cancer 124(2). p.420-428
Abstract
An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4, 1.1.2) for those aged <50 years and pOR 5.1 (95% CI: 3.6,... (More)
An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4, 1.1.2) for those aged <50 years and pOR 5.1 (95% CI: 3.6, 7.5) for those aged >= 50). The pOR for presence compared with absence of any clinically atypical nevi was 4.0 (95 % CI: 2.8, 5.8). The pORs for 1-2 and >= 3 large nevi on the body compared with none were 2.9 (95% CI: 1.9, 4.3) and 7.1 (95% CI: 4.7, 11.6), respectively. The relative heterogeneities among studies were small for most measures of nevus phenotype, except for the analysis of nevus counts on the arms, which may have been due to methodological differences among studies. The pooled analysis also suggested that an abnormal nevus phenotype is associated most with melanomas on intermittently sun-exposed sites. The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes. (C) 2008 Wiley-Liss, Inc. (Less)
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published
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keywords
Bayesian, pooled analysis, latitude, melanoma, nevus
in
International Journal of Cancer
volume
124
issue
2
pages
420 - 428
publisher
John Wiley & Sons
external identifiers
  • wos:000262010600022
  • scopus:58249084342
ISSN
0020-7136
DOI
10.1002/ijc.23869
language
English
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yes
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4a1a5ae2-9b08-4ed4-81f3-6f2b2eafd6a3 (old id 1313605)
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2009-03-09 15:38:28
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2017-12-10 03:50:59
@article{4a1a5ae2-9b08-4ed4-81f3-6f2b2eafd6a3,
  abstract     = {An abnormal nevus phenotype is associated with an increased risk of melanoma. We report a pooled analysis conducted using individual nevus data from 15 case-control studies (5,421 melanoma cases and 6,966 controls). The aims were to quantify the risk better and to determine whether relative risk is varied by latitude. Bayesian unconditional logistic random coefficients models were employed to study the risk associated with nevus characteristics. Participants with whole body nevus counts in the highest of 4 population-based categories had a greatly increased risk of melanoma compared with those in the lowest category (pooled odds ratio (pOR) 6.9 (95% confidence interval (CI): 4.4, 1.1.2) for those aged &lt;50 years and pOR 5.1 (95% CI: 3.6, 7.5) for those aged &gt;= 50). The pOR for presence compared with absence of any clinically atypical nevi was 4.0 (95 % CI: 2.8, 5.8). The pORs for 1-2 and &gt;= 3 large nevi on the body compared with none were 2.9 (95% CI: 1.9, 4.3) and 7.1 (95% CI: 4.7, 11.6), respectively. The relative heterogeneities among studies were small for most measures of nevus phenotype, except for the analysis of nevus counts on the arms, which may have been due to methodological differences among studies. The pooled analysis also suggested that an abnormal nevus phenotype is associated most with melanomas on intermittently sun-exposed sites. The presence of increased numbers of nevi, large nevi and clinically atypical nevi on the body are robust risk factors for melanoma showing little variation in relative risk among studies performed at different latitudes. (C) 2008 Wiley-Liss, Inc.},
  author       = {Chang, Yu-mei and Newton-Bishop, Julia A. and Bishop, D. Timothy and Armstrong, Bruce K. and Bataille, Veronique and Bergman, Wilma and Berwick, Marianne and Bracci, Paige M. and Elwood, J. Mark and Ernstoff, Marc S. and Green, Adele C. and Gruis, Nelleke A. and Holly, Elizabeth A. and Ingvar, Christian and Kanetsky, Peter A. and Karagas, Margaret R. and Le Marchand, Loic and Mackie, Rona M. and Olsson, Håkan and Osterlind, Anne and Rebbeck, Timothy R. and Reich, Kristian and Sasieni, Peter and Siskind, Victor and Swerdlow, Anthony I. and Titus-Ernstoff, Linda and Zens, Michael S. and Ziegler, Andreas and Barrett, Jennifer H.},
  issn         = {0020-7136},
  keyword      = {Bayesian,pooled analysis,latitude,melanoma,nevus},
  language     = {eng},
  number       = {2},
  pages        = {420--428},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {A pooled analysis of Melanocytic nevus phenotype and the risk of cutaneous melanoma at different latitudes},
  url          = {http://dx.doi.org/10.1002/ijc.23869},
  volume       = {124},
  year         = {2009},
}