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No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months

Willenheimer, Ronnie LU ; Juul-Möller, Steen LU ; Forslund, Lennart and Erhardt, Leif RW LU (2001) In Current Controlled Trials. Cardiovascular Medicine 2(2). p.99-105
Abstract
Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor... (More)
Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Controlled Trials. Cardiovascular Medicine
volume
2
issue
2
pages
99 - 105
publisher
BioMed Central
external identifiers
  • wos:000173941100005
  • scopus:17744393850
ISSN
1468-6694
DOI
10.1186/cvm-2-2-099
language
English
LU publication?
yes
id
8d0924e3-0051-49e7-a3f6-5b7c97654c40 (old id 131457)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=11806779&dopt=AbstractPlus
date added to LUP
2007-07-30 13:46:26
date last changed
2018-01-07 09:14:43
@article{8d0924e3-0051-49e7-a3f6-5b7c97654c40,
  abstract     = {Objective: To assess the effects of a 6-month angiotensin-converting enzyme (ACE) inhibitor intervention on myocardial ischaemia.Method: We randomized 389 patients with stable coronary artery disease to double-blind treatment with ramipril 5 mg/day (n = 133), ramipril 1.25 mg/day (n = 133), or placebo (n = 123). Forty-eight-hour ambulatory electrocardiography was performed at baseline, and after 1 and 6 months.Results: Relevant baseline variables were similar in all groups. Changes over 6 months in duration of 1 mm ST-segment depression (STD), total ischaemic burden and maximum STD did not differ significantly between the treatment groups. There was no difference in the frequency of adverse events between the groups.ConclusionACE inhibitor treatment has little impact on incidence and severity of myocardial ischaemia in patients with stable ischaemic heart disease.},
  author       = {Willenheimer, Ronnie and Juul-Möller, Steen and Forslund, Lennart and Erhardt, Leif RW},
  issn         = {1468-6694},
  language     = {eng},
  number       = {2},
  pages        = {99--105},
  publisher    = {BioMed Central},
  series       = {Current Controlled Trials. Cardiovascular Medicine},
  title        = {No effects on myocardial ischaemia in patients with stable ischaemic heart disease after treatment with ramipril for 6 months},
  url          = {http://dx.doi.org/10.1186/cvm-2-2-099},
  volume       = {2},
  year         = {2001},
}