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First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study

Hummel, Sandra; Beyerlein, Andreas; Tamura, Roy N.; Uusitalo, Ulla; Andŕen Aronsson, Carin LU ; Yang, Jimin; Riikonen, Anne; Lernmark, Ake LU ; Rewers, Marian J. and Hagopian, William A., et al. (2017) In Diabetes Care 40(3). p.398-404
Abstract

OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after... (More)

OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding 3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow'smilk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D .

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published
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Diabetes Care
volume
40
issue
3
pages
7 pages
publisher
American Diabetes Association
external identifiers
  • scopus:85019682125
  • wos:000395519100021
ISSN
0149-5992
DOI
10.2337/dc16-1624
language
English
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yes
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1316a7e3-b433-4920-8212-6a4d10135e76
date added to LUP
2017-06-16 11:26:47
date last changed
2018-01-07 12:08:08
@article{1316a7e3-b433-4920-8212-6a4d10135e76,
  abstract     = {<p>OBJECTIVE Studies on the introduction of infant formulas and its effect on the risk of islet autoimmunity and type 1 diabetes (T1D) have yielded inconsistent results. We investigated whether the introduction of formula based on hydrolyzed cow'smilk as the first formula is associated with reduced islet autoimmunity risk in a large prospective cohort. RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively monitors 8,676 children at increased genetic risk for T1D. Autoantibodies to insulin, GAD65, and IA2 were measured regularly to define islet autoimmunity. Information on formula feeding was collected by questionnaires at 3 months of age. RESULTS In survival analyses, after adjustment for family history with T1D, HLA genotype, sex, country, delivery mode, breast-feeding 3 months, and seasonality of birth, we observed no significant association with islet autoimmunity in infants who received extensively hydrolyzed compared with nonhydrolyzed cow'smilk-based formula as the first formula during the first 3 months (adjusted hazard ratio 1.38 [95% CI 0.95; 2.01]), and a significantly increased risk for extensively hydrolyzed formula introduced during the first 7 days (adjusted hazard ratio 1.57 [1.04; 2.38]). Using a partially hydrolyzed or other formula as the first formula, or no formula, was not associated with islet autoimmunity risk. CONCLUSIONS These results add to the existing evidence that islet autoimmunity risk is not reduced, and may be increased, by using hydrolyzed compared with nonhydrolyzed cow's milk-based infant formula as the first formula in infants at increased genetic risk for T1D .</p>},
  author       = {Hummel, Sandra and Beyerlein, Andreas and Tamura, Roy N. and Uusitalo, Ulla and Andŕen Aronsson, Carin and Yang, Jimin and Riikonen, Anne and Lernmark, Ake and Rewers, Marian J. and Hagopian, William A. and She, Jin-Xiong and Simell, Olli G. and Toppari, Jorma and Ziegler, Anette-G and Akolkar, Beena and Krischer, Jeffrey P. and Virtanen, Suvi M and Norris, Jill M},
  issn         = {0149-5992},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {398--404},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {First infant formula type and risk of islet autoimmunity in the environmental determinants of diabetes in the young (TEDDY) study},
  url          = {http://dx.doi.org/10.2337/dc16-1624},
  volume       = {40},
  year         = {2017},
}