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Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.

Lyssenko, Valeriya; Almgren, Peter LU ; Anevski, Dragi LU ; Perfekt, Roland LU ; Lahti, Kaj; Nissén, Michael; Isomaa, Bo; Forsen, Björn; Homström, Nils and Saloranta, Carola, et al. (2005) In Diabetes 54(1). p.166-174
Abstract
Identification of individuals at high risk of developing type 2 diabetes is a prerequisite for prevention of the disease. We therefore studied risk factors predicting type 2 diabetes in the Botnia Study in western Finland. A total of 2,115 nondiabetic individuals were prospectively followed with repeated oral glucose tolerance tests. After a median follow-up of 6 years, 127 (6%) subjects developed diabetes. A family history of diabetes (hazard ratio [HR] 2.2, P = 0.008), BMI (HR for comparison of values below or above the median 2.1, P < 0.001), waist-to-height index (2.3, P < 0.001), insulin resistance (2.1, P = 0.0004), and β-cell function adjusted for insulin resistance (2.7, P < 0.0001) predicted diabetes. Marked deterioration... (More)
Identification of individuals at high risk of developing type 2 diabetes is a prerequisite for prevention of the disease. We therefore studied risk factors predicting type 2 diabetes in the Botnia Study in western Finland. A total of 2,115 nondiabetic individuals were prospectively followed with repeated oral glucose tolerance tests. After a median follow-up of 6 years, 127 (6%) subjects developed diabetes. A family history of diabetes (hazard ratio [HR] 2.2, P = 0.008), BMI (HR for comparison of values below or above the median 2.1, P < 0.001), waist-to-height index (2.3, P < 0.001), insulin resistance (2.1, P = 0.0004), and β-cell function adjusted for insulin resistance (2.7, P < 0.0001) predicted diabetes. Marked deterioration in β-cell function with modest changes in insulin sensitivity was observed during the transition to diabetes. The combination of FPG ≥5.6 mmol/l, BMI ≥30 kg/m2, and family history of diabetes was a strong predictor of diabetes (3.7, P < 0.0001). Of note, using FPG ≥6.1 mmol/l or 2-h glucose ≥7.8 mmol/l did not significantly improve prediction of type 2 diabetes. In conclusion, a marked deterioration in β-cell function precedes the onset of type 2 diabetes. These individuals can be identified early by knowledge of FPG, BMI, and family history of diabetes. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
54
issue
1
pages
166 - 174
publisher
American Diabetes Association Inc.
external identifiers
  • wos:000226247500022
  • pmid:15616025
  • scopus:19944426903
ISSN
1939-327X
DOI
10.2337/diabetes.54.1.166
language
English
LU publication?
yes
id
3975055b-bc63-4ce1-9b0f-c1bc4186dc9b (old id 131866)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15616025&dopt=Abstract
date added to LUP
2007-07-26 09:52:40
date last changed
2017-11-19 04:06:49
@article{3975055b-bc63-4ce1-9b0f-c1bc4186dc9b,
  abstract     = {Identification of individuals at high risk of developing type 2 diabetes is a prerequisite for prevention of the disease. We therefore studied risk factors predicting type 2 diabetes in the Botnia Study in western Finland. A total of 2,115 nondiabetic individuals were prospectively followed with repeated oral glucose tolerance tests. After a median follow-up of 6 years, 127 (6%) subjects developed diabetes. A family history of diabetes (hazard ratio [HR] 2.2, P = 0.008), BMI (HR for comparison of values below or above the median 2.1, P &lt; 0.001), waist-to-height index (2.3, P &lt; 0.001), insulin resistance (2.1, P = 0.0004), and β-cell function adjusted for insulin resistance (2.7, P &lt; 0.0001) predicted diabetes. Marked deterioration in β-cell function with modest changes in insulin sensitivity was observed during the transition to diabetes. The combination of FPG ≥5.6 mmol/l, BMI ≥30 kg/m2, and family history of diabetes was a strong predictor of diabetes (3.7, P &lt; 0.0001). Of note, using FPG ≥6.1 mmol/l or 2-h glucose ≥7.8 mmol/l did not significantly improve prediction of type 2 diabetes. In conclusion, a marked deterioration in β-cell function precedes the onset of type 2 diabetes. These individuals can be identified early by knowledge of FPG, BMI, and family history of diabetes.},
  author       = {Lyssenko, Valeriya and Almgren, Peter and Anevski, Dragi and Perfekt, Roland and Lahti, Kaj and Nissén, Michael and Isomaa, Bo and Forsen, Björn and Homström, Nils and Saloranta, Carola and Taskinen, Marja-Riitta and Groop, Leif and Tuomi, Tiinamaija},
  issn         = {1939-327X},
  language     = {eng},
  number       = {1},
  pages        = {166--174},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.},
  url          = {http://dx.doi.org/10.2337/diabetes.54.1.166},
  volume       = {54},
  year         = {2005},
}