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Feedback control of Purkinje cell activity by the cerebello-olivary pathway.

Bengtsson, Fredrik LU ; Svensson, Pär LU and Hesslow, Germund LU (2004) In European Journal of Neuroscience 20(11). p.2999-3005
Abstract
The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an... (More)
The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
climbing fibres, cerebellum, deep cerebellar nuclei, inferior olive, nucleo-olivary pathway
in
European Journal of Neuroscience
volume
20
issue
11
pages
2999 - 3005
publisher
Wiley-Blackwell
external identifiers
  • wos:000225487800018
  • scopus:10844231910
ISSN
1460-9568
DOI
10.1111/j.1460-9568.2004.03789.x
language
English
LU publication?
yes
id
6cb95539-a63c-4f20-8e05-13747846533a (old id 132169)
date added to LUP
2007-07-10 11:28:15
date last changed
2017-01-15 03:34:35
@article{6cb95539-a63c-4f20-8e05-13747846533a,
  abstract     = {The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis.},
  author       = {Bengtsson, Fredrik and Svensson, Pär and Hesslow, Germund},
  issn         = {1460-9568},
  keyword      = {climbing fibres,cerebellum,deep cerebellar nuclei,inferior olive,nucleo-olivary pathway},
  language     = {eng},
  number       = {11},
  pages        = {2999--3005},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Neuroscience},
  title        = {Feedback control of Purkinje cell activity by the cerebello-olivary pathway.},
  url          = {http://dx.doi.org/10.1111/j.1460-9568.2004.03789.x},
  volume       = {20},
  year         = {2004},
}