Feedback control of Purkinje cell activity by the cerebello-olivary pathway.
(2004) In European Journal of Neuroscience 20(11). p.2999-3005- Abstract
- The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an... (More)
- The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132169
- author
- Bengtsson, Fredrik LU ; Svensson, Pär LU and Hesslow, Germund LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- climbing fibres, cerebellum, deep cerebellar nuclei, inferior olive, nucleo-olivary pathway
- in
- European Journal of Neuroscience
- volume
- 20
- issue
- 11
- pages
- 2999 - 3005
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000225487800018
- scopus:10844231910
- ISSN
- 1460-9568
- DOI
- 10.1111/j.1460-9568.2004.03789.x
- language
- English
- LU publication?
- yes
- id
- 6cb95539-a63c-4f20-8e05-13747846533a (old id 132169)
- date added to LUP
- 2016-04-01 12:08:24
- date last changed
- 2022-01-26 23:19:44
@article{6cb95539-a63c-4f20-8e05-13747846533a,
abstract = {{The pathway from the deep cerebellar nuclei to the inferior olive, the source of the climbing fibre input to the cerebellum, inhibits olivary transmission. As climbing fibre activity can depress the background firing of the Purkinje cells, it was suggested that nucleo-olivary (N–O) inhibition is a negative feedback mechanism for regulating Purkinje cell excitability. This suggestion was investigated, in a set-up with decerebrate ferrets, both by blocking and by stimulating cerebellar output while recording Purkinje cell activity. Blocking the N–O pathway was followed by an increased climbing fibre activity and a dramatic reduction in simple spike firing. Stimulation of the N–O fibres depressed climbing fibre responses and caused an increase in simple spike firing. These results are taken as support for the feedback hypothesis.}},
author = {{Bengtsson, Fredrik and Svensson, Pär and Hesslow, Germund}},
issn = {{1460-9568}},
keywords = {{climbing fibres; cerebellum; deep cerebellar nuclei; inferior olive; nucleo-olivary pathway}},
language = {{eng}},
number = {{11}},
pages = {{2999--3005}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neuroscience}},
title = {{Feedback control of Purkinje cell activity by the cerebello-olivary pathway.}},
url = {{https://lup.lub.lu.se/search/files/2798013/624284.pdf}},
doi = {{10.1111/j.1460-9568.2004.03789.x}},
volume = {{20}},
year = {{2004}},
}