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Intrauterine infection may be a major cause of stillbirth in Sweden

Tolockiene, Egle; Morsing, Eva LU ; Holst, Elisabeth; Herbst, Andreas LU ; Ljungh, Åsa LU ; Svenningsen, Nils; Hägerstrand, Inga and Nyström, Lennarth (2001) In Acta Obstetricia et Gynecologica Scandinavica 80(6). p.511-518
Abstract
Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth.



Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region.



Results. Chorioamnionitis was a common diagnosis both with stillbirths and 'healthy' deliveries (82 and 68%, respectively). Extension of the inflammation to decidua basalis was seven times more common among stillbirths than among controls (odds ratio 7.2, confidence interval 2.8-21.9). The most common bacteria found at cultures were Escherichia coli , Coagulase... (More)
Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth.



Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region.



Results. Chorioamnionitis was a common diagnosis both with stillbirths and 'healthy' deliveries (82 and 68%, respectively). Extension of the inflammation to decidua basalis was seven times more common among stillbirths than among controls (odds ratio 7.2, confidence interval 2.8-21.9). The most common bacteria found at cultures were Escherichia coli , Coagulase negative staphylococcus, Enterococcus faecalis and group B Streptococcus. The risk for stillbirth was doubled if both inflammation and bacteria were present (odds ratio 2.3, confidence interval 0.92-5.8). Meconium discharge was more common among stillbirths than controls (odds ratio=4.7, confidence interval 1.7-14). There were no differences in any respect regarding macerated and non-macerated stillbirths. Our findings are similar to the results from studies in developing countries except for the higher incidence of stillbirths in such countries.



Conclusions. Thus, a large part of otherwise unexplained stillbirths might be due to ascending infections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Obstetricia et Gynecologica Scandinavica
volume
80
issue
6
pages
511 - 518
publisher
Wiley-Blackwell
external identifiers
  • wos:000169176700005
  • scopus:0035010158
ISSN
1600-0412
DOI
10.1034/j.1600-0412.2001.d01-151.x
language
English
LU publication?
yes
id
6947aa4f-ccca-41da-9f3f-810718b4d3a4 (old id 132609)
date added to LUP
2007-07-10 14:32:05
date last changed
2018-05-29 11:20:44
@article{6947aa4f-ccca-41da-9f3f-810718b4d3a4,
  abstract     = {Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth.<br/><br>
<br/><br>
Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region.<br/><br>
<br/><br>
Results. Chorioamnionitis was a common diagnosis both with stillbirths and 'healthy' deliveries (82 and 68%, respectively). Extension of the inflammation to decidua basalis was seven times more common among stillbirths than among controls (odds ratio 7.2, confidence interval 2.8-21.9). The most common bacteria found at cultures were Escherichia coli , Coagulase negative staphylococcus, Enterococcus faecalis and group B Streptococcus. The risk for stillbirth was doubled if both inflammation and bacteria were present (odds ratio 2.3, confidence interval 0.92-5.8). Meconium discharge was more common among stillbirths than controls (odds ratio=4.7, confidence interval 1.7-14). There were no differences in any respect regarding macerated and non-macerated stillbirths. Our findings are similar to the results from studies in developing countries except for the higher incidence of stillbirths in such countries.<br/><br>
<br/><br>
Conclusions. Thus, a large part of otherwise unexplained stillbirths might be due to ascending infections.},
  author       = {Tolockiene, Egle and Morsing, Eva and Holst, Elisabeth and Herbst, Andreas and Ljungh, Åsa and Svenningsen, Nils and Hägerstrand, Inga and Nyström, Lennarth},
  issn         = {1600-0412},
  language     = {eng},
  number       = {6},
  pages        = {511--518},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Intrauterine infection may be a major cause of stillbirth in Sweden},
  url          = {http://dx.doi.org/10.1034/j.1600-0412.2001.d01-151.x},
  volume       = {80},
  year         = {2001},
}