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Molecularly imprinted polymers in capillary electrochromatography: Recent developments and future trends.

Spégel, Peter LU ; Schweitz, Leif LU and Nilsson, Staffan LU (2003) In Electrophoresis 24(22-23). p.3892-3899
Abstract
The developments in molecularly imprinted polymer (MIP)-based capillary electrochromatography (CEC) achieved during the past years are reviewed in this article. The MIP is prepared using a templated polymerization reaction and results in a material with a high selectivity towards a predetermined target. The selectivity of the MIP is comparable to that of the biological antibodies, however, the MIP is much more stable and is thus able to withstand extremely harsh conditions in terms of pH, temperature, and organic solvents. The high selectivity and stability of the MIP made it an interesting candidate for application as stationary phase sorbent in chromatography. However, due to slow kinetics the efficiency of the early MIP columns, which... (More)
The developments in molecularly imprinted polymer (MIP)-based capillary electrochromatography (CEC) achieved during the past years are reviewed in this article. The MIP is prepared using a templated polymerization reaction and results in a material with a high selectivity towards a predetermined target. The selectivity of the MIP is comparable to that of the biological antibodies, however, the MIP is much more stable and is thus able to withstand extremely harsh conditions in terms of pH, temperature, and organic solvents. The high selectivity and stability of the MIP made it an interesting candidate for application as stationary phase sorbent in chromatography. However, due to slow kinetics the efficiency of the early MIP columns, which were predominantly applied in high-performance liquid chromatography (HPLC), were limited. The use of CEC was thought to improve the efficiency of the MIP-based separation system. The small dimensions of the capillary format employed in CEC have put demands on the polymer systems which have resulted in the development of many different polymer formats. Thus, this need for novel MIP formats for applications in CEC has contributed a lot to the general development of MIP formats as well as to the knowledge in MIP synthesis and characteristics. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
capillary electrochromatography, review, molecularly imprinted polymer
in
Electrophoresis
volume
24
issue
22-23
pages
3892 - 3899
publisher
John Wiley & Sons
external identifiers
  • wos:000187428500005
  • pmid:14661224
  • scopus:0347089221
ISSN
0173-0835
DOI
10.1002/elps.200305665
language
English
LU publication?
yes
id
159ea6a8-742b-4193-8518-51a01a9a6ee2 (old id 132755)
date added to LUP
2007-06-27 16:16:33
date last changed
2018-01-07 05:22:59
@article{159ea6a8-742b-4193-8518-51a01a9a6ee2,
  abstract     = {The developments in molecularly imprinted polymer (MIP)-based capillary electrochromatography (CEC) achieved during the past years are reviewed in this article. The MIP is prepared using a templated polymerization reaction and results in a material with a high selectivity towards a predetermined target. The selectivity of the MIP is comparable to that of the biological antibodies, however, the MIP is much more stable and is thus able to withstand extremely harsh conditions in terms of pH, temperature, and organic solvents. The high selectivity and stability of the MIP made it an interesting candidate for application as stationary phase sorbent in chromatography. However, due to slow kinetics the efficiency of the early MIP columns, which were predominantly applied in high-performance liquid chromatography (HPLC), were limited. The use of CEC was thought to improve the efficiency of the MIP-based separation system. The small dimensions of the capillary format employed in CEC have put demands on the polymer systems which have resulted in the development of many different polymer formats. Thus, this need for novel MIP formats for applications in CEC has contributed a lot to the general development of MIP formats as well as to the knowledge in MIP synthesis and characteristics.},
  author       = {Spégel, Peter and Schweitz, Leif and Nilsson, Staffan},
  issn         = {0173-0835},
  keyword      = {capillary electrochromatography,review,molecularly imprinted polymer},
  language     = {eng},
  number       = {22-23},
  pages        = {3892--3899},
  publisher    = {John Wiley & Sons},
  series       = {Electrophoresis},
  title        = {Molecularly imprinted polymers in capillary electrochromatography: Recent developments and future trends.},
  url          = {http://dx.doi.org/10.1002/elps.200305665},
  volume       = {24},
  year         = {2003},
}