Advanced

Selectivity toward multiple predetermined targets in nanoparticle capillary electrochromatography.

Spégel, Peter LU ; Schweitz, Leif LU and Nilsson, Staffan LU (2003) In Analytical Chemistry 75(23). p.6608-6613
Abstract
Two unique methods to achieve selectivity toward multiple predetermined targets employing molecular imprinting technology have been developed. Partial filling capillary electrochromatography (CEC) was utilized to evaluate and compare the two techniques. The first approach, the mixed singly templated molecularly imprinted polymer (MIP) nanoparticle approach, is based on the mixing of two types of MIP nanoparticles with inherently different selectivity. The second approach, the multiply templated MIP nanoparticle approach, is based on the incorporation of two different templates during the preparation of the MIP nanoparticles. The use of MIPs in analytical chemistry applications has been extensively investigated during the past years.... (More)
Two unique methods to achieve selectivity toward multiple predetermined targets employing molecular imprinting technology have been developed. Partial filling capillary electrochromatography (CEC) was utilized to evaluate and compare the two techniques. The first approach, the mixed singly templated molecularly imprinted polymer (MIP) nanoparticle approach, is based on the mixing of two types of MIP nanoparticles with inherently different selectivity. The second approach, the multiply templated MIP nanoparticle approach, is based on the incorporation of two different templates during the preparation of the MIP nanoparticles. The use of MIPs in analytical chemistry applications has been extensively investigated during the past years. However, MIP nanoparticles with tailored multiple selectivity toward predetermined enantiomers has not yet been explored. The relative amounts of the two templates studied, i.e., (S)-ropivacaine and (S)-propranolol, were found to strongly affect the affinity of the multiply templated MIP nanoparticles for the predetermined targets. The amount of (S)-propranolol template had to be decreased to concentrations rarely applied in MIP synthesis in order to achieve 2-fold selectivity. Even though strongly decreased to 10% of the usual concentration employed, the MIP could efficiently separate the enantiomers of propranolol when applied in partial filling CEC. This opens up for new possibilities to decrease the need for an initial high amount of template in order to be able to produce an efficient MIP. The multiple enantiomer separation ability of the multiply templated MIP nanoparticles was compared with that of singly templated MIP nanoparticles that were mixed prior to analysis. It was concluded that the multiply templated MIP potentially can offer many new and interesting applications in chromatography as well as in sensor technology and solid-phase extraction. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
75
issue
23
pages
6608 - 6613
publisher
The American Chemical Society
external identifiers
  • wos:000186986000037
  • pmid:16465715
  • scopus:0344305765
ISSN
1520-6882
DOI
language
English
LU publication?
yes
id
217657ca-bc27-4c45-9642-98b1e6532c1a (old id 132760)
date added to LUP
2007-06-27 16:18:18
date last changed
2018-06-17 03:57:43
@article{217657ca-bc27-4c45-9642-98b1e6532c1a,
  abstract     = {Two unique methods to achieve selectivity toward multiple predetermined targets employing molecular imprinting technology have been developed. Partial filling capillary electrochromatography (CEC) was utilized to evaluate and compare the two techniques. The first approach, the mixed singly templated molecularly imprinted polymer (MIP) nanoparticle approach, is based on the mixing of two types of MIP nanoparticles with inherently different selectivity. The second approach, the multiply templated MIP nanoparticle approach, is based on the incorporation of two different templates during the preparation of the MIP nanoparticles. The use of MIPs in analytical chemistry applications has been extensively investigated during the past years. However, MIP nanoparticles with tailored multiple selectivity toward predetermined enantiomers has not yet been explored. The relative amounts of the two templates studied, i.e., (S)-ropivacaine and (S)-propranolol, were found to strongly affect the affinity of the multiply templated MIP nanoparticles for the predetermined targets. The amount of (S)-propranolol template had to be decreased to concentrations rarely applied in MIP synthesis in order to achieve 2-fold selectivity. Even though strongly decreased to 10% of the usual concentration employed, the MIP could efficiently separate the enantiomers of propranolol when applied in partial filling CEC. This opens up for new possibilities to decrease the need for an initial high amount of template in order to be able to produce an efficient MIP. The multiple enantiomer separation ability of the multiply templated MIP nanoparticles was compared with that of singly templated MIP nanoparticles that were mixed prior to analysis. It was concluded that the multiply templated MIP potentially can offer many new and interesting applications in chromatography as well as in sensor technology and solid-phase extraction.},
  author       = {Spégel, Peter and Schweitz, Leif and Nilsson, Staffan},
  issn         = {1520-6882},
  language     = {eng},
  number       = {23},
  pages        = {6608--6613},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {Selectivity toward multiple predetermined targets in nanoparticle capillary electrochromatography.},
  url          = {http://dx.doi.org/},
  volume       = {75},
  year         = {2003},
}