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Screening för celiaki kan vara motiverad i högriskgrupper

Sjöberg, Klas LU and Carlsson, Annelie LU (2004) In Läkartidningen 101(48). p.6-3915
Abstract (Swedish)
Celiaki förekommer hos 0,5–1 procent av befolkningen.

Majoriteten av dem med celiaki har atypiska symtom

och är inte diagnostiserade.

Personer med vissa kromosomrubbningar eller annan

autoimmun sjukdom och nära släktingar till personer

med celiaki tillhör riskgrupper där screening

kan rekommenderas.

IgA-endomysie- eller IgA-transglutaminasantikroppar

har båda hög specificitet och hög sensitivitet för

celiaki och används idag för screening. Vid IgA-brist

kan IgG-antikroppar analyseras i stället.

IgA-gliadinantikroppar är ofta falskt positiva men är

trots detta den bästa markören hos barn under 2 år.

Celiaki är oftast... (More)
Celiaki förekommer hos 0,5–1 procent av befolkningen.

Majoriteten av dem med celiaki har atypiska symtom

och är inte diagnostiserade.

Personer med vissa kromosomrubbningar eller annan

autoimmun sjukdom och nära släktingar till personer

med celiaki tillhör riskgrupper där screening

kan rekommenderas.

IgA-endomysie- eller IgA-transglutaminasantikroppar

har båda hög specificitet och hög sensitivitet för

celiaki och används idag för screening. Vid IgA-brist

kan IgG-antikroppar analyseras i stället.

IgA-gliadinantikroppar är ofta falskt positiva men är

trots detta den bästa markören hos barn under 2 år.

Celiaki är oftast HLA-associerad, i de flesta fall till

DQ2 (80 procent) annars till DQ8 (20 procent). Ett alternativ

i framtiden kan vara att i vissa riskgrupper

först bestämma HLA-typ och därefter antikroppstiter.

Biopsi är fortfarande etablerad standardmetod för att

bekräfta diagnosen celiaki. (Less)
Abstract
Coeliac disease is widespread and occurs in 0.5-1 per cent of the population. Most sufferers show atypical symptoms and might well remain undiagnosed. Endomysial or human transglutaminase autoantibody levels of type IgA can be recommended as screening instruments combined with s-IgA for exclusion of such deficiency. In contrast, there is a high frequency of false-positive IgA gliadin antibody test results, especially where coeliac disease is common, as in chronic liver disease, diabetes, thyroid disease and conditions with chromosomal aberrations (Down syndrome and Turner syndrome). Despite this, gliadin antibodies of type IgA are still the best marker for coeliac disease in children under two years of age. While mass screening is not to... (More)
Coeliac disease is widespread and occurs in 0.5-1 per cent of the population. Most sufferers show atypical symptoms and might well remain undiagnosed. Endomysial or human transglutaminase autoantibody levels of type IgA can be recommended as screening instruments combined with s-IgA for exclusion of such deficiency. In contrast, there is a high frequency of false-positive IgA gliadin antibody test results, especially where coeliac disease is common, as in chronic liver disease, diabetes, thyroid disease and conditions with chromosomal aberrations (Down syndrome and Turner syndrome). Despite this, gliadin antibodies of type IgA are still the best marker for coeliac disease in children under two years of age. While mass screening is not to be recommended, case finding is worthwhile in well defined risk groups, i.e. in cohorts with autoimmune disease or chromosomal aberrations or in relatives to anyone with coeliac disease. A positive biopsy is still the gold standard for diagnosis. (Less)
Please use this url to cite or link to this publication:
author
organization
alternative title
Screening for celiac disease can be justified in high-risk groups
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Gliadin: immunology, English Abstract, Child, Celiac Disease: immunology, Celiac Disease: genetics, Celiac Disease: diagnosis, Celiac Disease: complications, Biological Markers: blood, Autoimmune Diseases: diagnosis, Adult, Autoimmune Diseases: complications, Transglutaminases: immunology, Risk Factors, Myosins: immunology, Immunoglobulin A: blood, Mass Screening
in
Läkartidningen
volume
101
issue
48
pages
6 - 3915
publisher
Swedish Medical Association
external identifiers
  • scopus:10044254744
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
4b062aaf-d3af-4e20-bbb4-fe355a75752e (old id 133316)
alternative location
http://ltarkiv.lakartidningen.se/artNo29478
date added to LUP
2007-07-30 16:01:46
date last changed
2017-10-08 04:12:12
@article{4b062aaf-d3af-4e20-bbb4-fe355a75752e,
  abstract     = {Coeliac disease is widespread and occurs in 0.5-1 per cent of the population. Most sufferers show atypical symptoms and might well remain undiagnosed. Endomysial or human transglutaminase autoantibody levels of type IgA can be recommended as screening instruments combined with s-IgA for exclusion of such deficiency. In contrast, there is a high frequency of false-positive IgA gliadin antibody test results, especially where coeliac disease is common, as in chronic liver disease, diabetes, thyroid disease and conditions with chromosomal aberrations (Down syndrome and Turner syndrome). Despite this, gliadin antibodies of type IgA are still the best marker for coeliac disease in children under two years of age. While mass screening is not to be recommended, case finding is worthwhile in well defined risk groups, i.e. in cohorts with autoimmune disease or chromosomal aberrations or in relatives to anyone with coeliac disease. A positive biopsy is still the gold standard for diagnosis.},
  author       = {Sjöberg, Klas and Carlsson, Annelie},
  issn         = {0023-7205},
  keyword      = {Humans,Gliadin: immunology,English Abstract,Child,Celiac Disease: immunology,Celiac Disease: genetics,Celiac Disease: diagnosis,Celiac Disease: complications,Biological Markers: blood,Autoimmune Diseases: diagnosis,Adult,Autoimmune Diseases: complications,Transglutaminases: immunology,Risk Factors,Myosins: immunology,Immunoglobulin A: blood,Mass Screening},
  language     = {swe},
  number       = {48},
  pages        = {6--3915},
  publisher    = {Swedish Medical Association},
  series       = {Läkartidningen},
  title        = {Screening för celiaki kan vara motiverad i högriskgrupper},
  volume       = {101},
  year         = {2004},
}