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In vitro fertilization (IVF) in Sweden: Risk for congenital malformations after different IVF methods.

Källén, Bengt LU ; Finnström, Orvar; Nygren, Karl Gösta and Olausson, Petra Otterblad (2005) In Birth Defects Research. Clinical and Molecular Teratology 73(3). p.162-169
Abstract
BACKGROUND: The possible excess of congenital malformations in infants born after in vitro fertilization (IVF) has been much discussed in the literature, with controversial conclusions. This population based study is aimed at analyzing the presence of congenital malformations in a large group of infants born after IVF and to compare malformation risk both with that of all infants born and according to IVF method used. METHODS: Infants born after IVF during the period 1982-2001 were ascertained from all IVF clinics in Sweden. The presence of congenital malformations was identified from three national health registers: the Swedish Medical Birth Register, the Swedish Registry of Congenital Malformations, and the Swedish Hospital Discharge... (More)
BACKGROUND: The possible excess of congenital malformations in infants born after in vitro fertilization (IVF) has been much discussed in the literature, with controversial conclusions. This population based study is aimed at analyzing the presence of congenital malformations in a large group of infants born after IVF and to compare malformation risk both with that of all infants born and according to IVF method used. METHODS: Infants born after IVF during the period 1982-2001 were ascertained from all IVF clinics in Sweden. The presence of congenital malformations was identified from three national health registers: the Swedish Medical Birth Register, the Swedish Registry of Congenital Malformations, and the Swedish Hospital Discharge Register. The IVF children were compared with all children born in Sweden during the same period and recorded in the Swedish Medical Birth Register. RESULTS: Among 16,280 IVF children (30% conceived after intracytoplasmatic sperm injection [ICSI]) a 42% excess of any congenital malformation was found, explainable by parental characteristics and in some cases by the high rate of multiple births. Among these children, 8% had a congenital malformation, and 5% had a relatively severe condition. For neural tube defects, choanal atresia, and alimentary tract atresia, an additional risk increase was seen. There was no difference in malformation rate according to IVF method except for an excess of hypospadias after ICSI. CONCLUSIONS: An increased risk for congenital malformations occurs after IVF, similar for the different IVF techniques used, and mainly a consequence of parental characteristics. A few specific conditions show an extra increase in risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
in vitro fertilization, neural tube defects, congenital malformations, alimentary atresia, hypospadias
in
Birth Defects Research. Clinical and Molecular Teratology
volume
73
issue
3
pages
162 - 169
publisher
John Wiley & Sons
external identifiers
  • wos:000228049200007
  • pmid:15678490
  • scopus:16444362792
ISSN
1542-0760
DOI
10.1002/bdra.20107
language
English
LU publication?
yes
id
943ce642-1930-4c46-9ff1-200b4c445171 (old id 134006)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15678490&dopt=Abstract
date added to LUP
2007-07-24 15:42:39
date last changed
2017-09-24 03:42:54
@article{943ce642-1930-4c46-9ff1-200b4c445171,
  abstract     = {BACKGROUND: The possible excess of congenital malformations in infants born after in vitro fertilization (IVF) has been much discussed in the literature, with controversial conclusions. This population based study is aimed at analyzing the presence of congenital malformations in a large group of infants born after IVF and to compare malformation risk both with that of all infants born and according to IVF method used. METHODS: Infants born after IVF during the period 1982-2001 were ascertained from all IVF clinics in Sweden. The presence of congenital malformations was identified from three national health registers: the Swedish Medical Birth Register, the Swedish Registry of Congenital Malformations, and the Swedish Hospital Discharge Register. The IVF children were compared with all children born in Sweden during the same period and recorded in the Swedish Medical Birth Register. RESULTS: Among 16,280 IVF children (30% conceived after intracytoplasmatic sperm injection [ICSI]) a 42% excess of any congenital malformation was found, explainable by parental characteristics and in some cases by the high rate of multiple births. Among these children, 8% had a congenital malformation, and 5% had a relatively severe condition. For neural tube defects, choanal atresia, and alimentary tract atresia, an additional risk increase was seen. There was no difference in malformation rate according to IVF method except for an excess of hypospadias after ICSI. CONCLUSIONS: An increased risk for congenital malformations occurs after IVF, similar for the different IVF techniques used, and mainly a consequence of parental characteristics. A few specific conditions show an extra increase in risk.},
  author       = {Källén, Bengt and Finnström, Orvar and Nygren, Karl Gösta and Olausson, Petra Otterblad},
  issn         = {1542-0760},
  keyword      = {in vitro fertilization,neural tube defects,congenital malformations,alimentary atresia,hypospadias},
  language     = {eng},
  number       = {3},
  pages        = {162--169},
  publisher    = {John Wiley & Sons},
  series       = {Birth Defects Research. Clinical and Molecular Teratology},
  title        = {In vitro fertilization (IVF) in Sweden: Risk for congenital malformations after different IVF methods.},
  url          = {http://dx.doi.org/10.1002/bdra.20107},
  volume       = {73},
  year         = {2005},
}