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Chlamydia trachomatis infection and persistence of human papillomavirus.

Silins, Ilvars LU ; Ryd, Walter; Strand, Anders; Wadell, Göran; Törnberg, Sven; Hansson, Bengt-Göran LU ; Wang, Xiaohong LU ; Arnheim, Lisen; Dahl, Viktor and Bremell, Daniel, et al. (2005) In International Journal of Cancer 116(1). p.110-115
Abstract
Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known. Chlamydia (C.) trachomatis infection seems to also be associated with cervical cancer. We investigated whether C. trachomatis infection is a risk factor for HPV persistence. In a cohort of 12,527 women participating in a population-based HPV screening trial in Sweden, 6,418 women completed testing for HPV DNA by general primer PCR and typing by reverse dot blot hybridization. On average 19 months later, 303 women that had been HPV-positive and had normal cytology at enrollment completed a new HPV test. Environmental exposures were assessed by an 87-itern... (More)
Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known. Chlamydia (C.) trachomatis infection seems to also be associated with cervical cancer. We investigated whether C. trachomatis infection is a risk factor for HPV persistence. In a cohort of 12,527 women participating in a population-based HPV screening trial in Sweden, 6,418 women completed testing for HPV DNA by general primer PCR and typing by reverse dot blot hybridization. On average 19 months later, 303 women that had been HPV-positive and had normal cytology at enrollment completed a new HPV test. Environmental exposures were assessed by an 87-itern questionnaire. Previous sexually transmitted infections were also investigated by serology. At follow-up, 44% of the women were positive for the same type of HPV DNA as at enrollment. Persistence correlated with length of follow-up (p < 0.01) and condom use seemed to protect against HPV persistence (p < 0.05). The most significant risk factor for persistent presence of HPV DNA was self-reported history of previous C. trachomatis infection (relative risk in multivariate model = 2.09; 95% confidence interval = 1.05-4.18). We conclude that persistence of oncogenic HPV infections is more likely among women with a previous C. trachomatis infection. (Less)
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published
subject
keywords
epidemiology, HPV persistence, Chlamydia trachomatis, HPV infection
in
International Journal of Cancer
volume
116
issue
1
pages
110 - 115
publisher
John Wiley & Sons
external identifiers
  • pmid:15756673
  • wos:000229766100017
  • scopus:20444464469
ISSN
0020-7136
DOI
10.1002/ijc.20970
language
English
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yes
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5c882bab-f058-4b9d-94d3-6746802bfb5e (old id 135081)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15756673&dopt=Abstract
date added to LUP
2007-07-27 08:43:22
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2017-11-05 03:31:50
@article{5c882bab-f058-4b9d-94d3-6746802bfb5e,
  abstract     = {Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known. Chlamydia (C.) trachomatis infection seems to also be associated with cervical cancer. We investigated whether C. trachomatis infection is a risk factor for HPV persistence. In a cohort of 12,527 women participating in a population-based HPV screening trial in Sweden, 6,418 women completed testing for HPV DNA by general primer PCR and typing by reverse dot blot hybridization. On average 19 months later, 303 women that had been HPV-positive and had normal cytology at enrollment completed a new HPV test. Environmental exposures were assessed by an 87-itern questionnaire. Previous sexually transmitted infections were also investigated by serology. At follow-up, 44% of the women were positive for the same type of HPV DNA as at enrollment. Persistence correlated with length of follow-up (p &lt; 0.01) and condom use seemed to protect against HPV persistence (p &lt; 0.05). The most significant risk factor for persistent presence of HPV DNA was self-reported history of previous C. trachomatis infection (relative risk in multivariate model = 2.09; 95% confidence interval = 1.05-4.18). We conclude that persistence of oncogenic HPV infections is more likely among women with a previous C. trachomatis infection.},
  author       = {Silins, Ilvars and Ryd, Walter and Strand, Anders and Wadell, Göran and Törnberg, Sven and Hansson, Bengt-Göran and Wang, Xiaohong and Arnheim, Lisen and Dahl, Viktor and Bremell, Daniel and Persson, Kenneth and Dillner, Joakim and Rylander, Eva},
  issn         = {0020-7136},
  keyword      = {epidemiology,HPV persistence,Chlamydia trachomatis,HPV infection},
  language     = {eng},
  number       = {1},
  pages        = {110--115},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Chlamydia trachomatis infection and persistence of human papillomavirus.},
  url          = {http://dx.doi.org/10.1002/ijc.20970},
  volume       = {116},
  year         = {2005},
}