Posterior Insular Molecular Changes in Myofascial Pain
Gerstner, G. E. ; Gracely, R. H. ; Deebajah, A. ; Ichesco, E. ; Quintero, A. ; Clauw, D. J. and Sundgren, Pia LU
(2012)
In Journal of Dental Research
91(5).
p.485-490
- Abstract
- Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy (H-1-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control... (More)
- Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy (H-1-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control individuals, and NAA levels were significantly correlated with pain-symptom duration, suggesting adaptive changes. The results suggest that significant central cellular and molecular changes can occur in individuals with TMD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2570914
- author
- Gerstner, G. E.
; Gracely, R. H.
; Deebajah, A.
; Ichesco, E.
; Quintero, A.
; Clauw, D. J.
and Sundgren, Pia
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- magnetic resonance spectroscopy, temporomandibular disorders, N-acetyl, aspartate, choline, glutamate, glutamine
- in
- Journal of Dental Research
- volume
- 91
- issue
- 5
- pages
- 485 - 490
- publisher
- International & American Associations for Dental Research
- external identifiers
-
- wos:000302916300009
- scopus:84859899301
- ISSN
- 0022-0345
- DOI
- 10.1177/0022034512443366
- language
- English
- LU publication?
- yes
- id
- 135abdf8-2bb0-43c6-aa36-fc577ce8d7ef (old id 2570914)
- date added to LUP
- 2016-04-01 10:30:03
- date last changed
- 2022-02-02 18:24:34
@article{135abdf8-2bb0-43c6-aa36-fc577ce8d7ef,
abstract = {{Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy (H-1-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control individuals, and NAA levels were significantly correlated with pain-symptom duration, suggesting adaptive changes. The results suggest that significant central cellular and molecular changes can occur in individuals with TMD.}},
author = {{Gerstner, G. E. and Gracely, R. H. and Deebajah, A. and Ichesco, E. and Quintero, A. and Clauw, D. J. and Sundgren, Pia}},
issn = {{0022-0345}},
keywords = {{magnetic resonance spectroscopy; temporomandibular disorders; N-acetyl; aspartate; choline; glutamate; glutamine}},
language = {{eng}},
number = {{5}},
pages = {{485--490}},
publisher = {{International & American Associations for Dental Research}},
series = {{Journal of Dental Research}},
title = {{Posterior Insular Molecular Changes in Myofascial Pain}},
url = {{http://dx.doi.org/10.1177/0022034512443366}},
doi = {{10.1177/0022034512443366}},
volume = {{91}},
year = {{2012}},
}