Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers.
Goncalves, Isabel LU
; Cherfan, Pierre
; Söderberg, Ingrid
LU
; Nordin Fredrikson, Gunilla
LU
and Jonasson, Lena
(2009)
In Autoimmunity
42(3).
p.203-208
- Abstract
- Statins exert a number of anti-inflammatory and immunomodulatory effects in vitro. However, the immunomodulatory effects in vivo are less clarified. In the present study, we investigated whether simvastatin treatment changed the levels of autoantibodies against specific oxidized LDL (oxLDL) antigens as well as their association with leukocyte activation markers. Eighty volunteers with mild-to-moderate hypercholesterolemia were randomized to either simvastatin 40 mg or placebo for 6 weeks. Autoantibodies against apo B peptide antigens, C-reactive protein (CRP) and interleukin (IL)-6 in plasma were determined by ELISA. Subsets of circulating B and T cells were studied by flow cytometry. Simvastatin significantly reduced CRP by 26%, whereas... (More)
- Statins exert a number of anti-inflammatory and immunomodulatory effects in vitro. However, the immunomodulatory effects in vivo are less clarified. In the present study, we investigated whether simvastatin treatment changed the levels of autoantibodies against specific oxidized LDL (oxLDL) antigens as well as their association with leukocyte activation markers. Eighty volunteers with mild-to-moderate hypercholesterolemia were randomized to either simvastatin 40 mg or placebo for 6 weeks. Autoantibodies against apo B peptide antigens, C-reactive protein (CRP) and interleukin (IL)-6 in plasma were determined by ELISA. Subsets of circulating B and T cells were studied by flow cytometry. Simvastatin significantly reduced CRP by 26%, whereas IL-6 remained unchanged. Levels of IgG against the apo B peptide P-240 (amino acids 3586-3605) increased by 16% (p = 0.03) in the simvastatin group whereas autoantibody levels to other apo B peptides did not change. At baseline and after 6 weeks, the P-240 IgG levels were significantly correlated with the number of CD57+CD28 - CD8+T cells but not to other lymphocyte subsets or inflammatory markers. The P-240 IgG levels after 6 weeks simvastatin therapy was strongly correlated to the relative increase in CD57+CD28 - CD8+T cells (p = 0.003). Simvastatin treatment induced an increase in autoantibodies against an oxLDL antigen. The effect was related to an expansion of a CD8+T cell subset and may involve an immunostimulation by simvastatin. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367599
- author
- Goncalves, Isabel
LU
; Cherfan, Pierre
; Söderberg, Ingrid
LU
; Nordin Fredrikson, Gunilla
LU
and Jonasson, Lena
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Autoimmunity
- volume
- 42
- issue
- 3
- pages
- 203 - 208
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000264346000004
- pmid:19301201
- scopus:67649650136
- pmid:19301201
- ISSN
- 0891-6934
- DOI
- 10.1080/08916930802668602
- language
- English
- LU publication?
- yes
- id
- 23e295ee-3d02-4601-93d2-a3511f4c7295 (old id 1367599)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19301201?dopt=Abstract
- date added to LUP
- 2016-04-04 09:12:11
- date last changed
- 2022-02-07 11:26:07
@article{23e295ee-3d02-4601-93d2-a3511f4c7295,
abstract = {{Statins exert a number of anti-inflammatory and immunomodulatory effects in vitro. However, the immunomodulatory effects in vivo are less clarified. In the present study, we investigated whether simvastatin treatment changed the levels of autoantibodies against specific oxidized LDL (oxLDL) antigens as well as their association with leukocyte activation markers. Eighty volunteers with mild-to-moderate hypercholesterolemia were randomized to either simvastatin 40 mg or placebo for 6 weeks. Autoantibodies against apo B peptide antigens, C-reactive protein (CRP) and interleukin (IL)-6 in plasma were determined by ELISA. Subsets of circulating B and T cells were studied by flow cytometry. Simvastatin significantly reduced CRP by 26%, whereas IL-6 remained unchanged. Levels of IgG against the apo B peptide P-240 (amino acids 3586-3605) increased by 16% (p = 0.03) in the simvastatin group whereas autoantibody levels to other apo B peptides did not change. At baseline and after 6 weeks, the P-240 IgG levels were significantly correlated with the number of CD57+CD28 - CD8+T cells but not to other lymphocyte subsets or inflammatory markers. The P-240 IgG levels after 6 weeks simvastatin therapy was strongly correlated to the relative increase in CD57+CD28 - CD8+T cells (p = 0.003). Simvastatin treatment induced an increase in autoantibodies against an oxLDL antigen. The effect was related to an expansion of a CD8+T cell subset and may involve an immunostimulation by simvastatin.}},
author = {{Goncalves, Isabel and Cherfan, Pierre and Söderberg, Ingrid and Nordin Fredrikson, Gunilla and Jonasson, Lena}},
issn = {{0891-6934}},
language = {{eng}},
number = {{3}},
pages = {{203--208}},
publisher = {{Taylor & Francis}},
series = {{Autoimmunity}},
title = {{Effects of simvastatin on circulating autoantibodies to oxidized LDL antigens: relation with immune stimulation markers.}},
url = {{http://dx.doi.org/10.1080/08916930802668602}},
doi = {{10.1080/08916930802668602}},
volume = {{42}},
year = {{2009}},
}