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Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety.

Wiehager, Sara LU ; Beiderbeck, Daniela I; Gruber, Susanne H M; El-Khoury, Aram; Wamsteeker, Jackie; Neumann, Inga D; Petersén, Åsa LU and Mathé, Aleksander A (2009) In Neurobiology of Disease 34. p.375-380
Abstract
The neurobiological bases of mood disorders remain elusive but both monoamines and neuropeptides may play important roles. The neuropeptide cocaine and amphetamine regulated transcript (CART) was shown to induce anxiety-like behavior in rodents, and mutations in the human CART gene are associated with depression and anxiety. We measured CART-like immunoreactivity (-LI) in genetic rat models of depression and anxiety, i.e. the Flinders Sensitive Line (FSL) and rats selected for High Anxiety-related Behavior (HAB) using a radioimmunoassay. CART-LI was significantly increased in the periaqueductal grey in FSL rats, whereas in the HAB strain it was increased in the hypothalamus, both compared with their respective controls. No line-dependent... (More)
The neurobiological bases of mood disorders remain elusive but both monoamines and neuropeptides may play important roles. The neuropeptide cocaine and amphetamine regulated transcript (CART) was shown to induce anxiety-like behavior in rodents, and mutations in the human CART gene are associated with depression and anxiety. We measured CART-like immunoreactivity (-LI) in genetic rat models of depression and anxiety, i.e. the Flinders Sensitive Line (FSL) and rats selected for High Anxiety-related Behavior (HAB) using a radioimmunoassay. CART-LI was significantly increased in the periaqueductal grey in FSL rats, whereas in the HAB strain it was increased in the hypothalamus, both compared with their respective controls. No line-dependent changes were found in the hippocampus, striatum or frontal cortex. Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Disease
volume
34
pages
375 - 380
publisher
Elsevier
external identifiers
  • wos:000265869400019
  • pmid:19254763
  • scopus:64649094238
ISSN
0969-9961
DOI
10.1016/j.nbd.2009.02.010
language
English
LU publication?
yes
id
456dd0e2-ca94-48f2-97b8-565ad83d3d20 (old id 1368080)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19254763?dopt=Abstract
date added to LUP
2009-04-03 12:18:02
date last changed
2017-01-15 04:23:18
@article{456dd0e2-ca94-48f2-97b8-565ad83d3d20,
  abstract     = {The neurobiological bases of mood disorders remain elusive but both monoamines and neuropeptides may play important roles. The neuropeptide cocaine and amphetamine regulated transcript (CART) was shown to induce anxiety-like behavior in rodents, and mutations in the human CART gene are associated with depression and anxiety. We measured CART-like immunoreactivity (-LI) in genetic rat models of depression and anxiety, i.e. the Flinders Sensitive Line (FSL) and rats selected for High Anxiety-related Behavior (HAB) using a radioimmunoassay. CART-LI was significantly increased in the periaqueductal grey in FSL rats, whereas in the HAB strain it was increased in the hypothalamus, both compared with their respective controls. No line-dependent changes were found in the hippocampus, striatum or frontal cortex. Our results confirm human genetic studies indicating CART as a neurobiological correlate of depression and anxiety, and suggest that its differential regulation in specific brain regions may play a role for the behavioral phenotypes.},
  author       = {Wiehager, Sara and Beiderbeck, Daniela I and Gruber, Susanne H M and El-Khoury, Aram and Wamsteeker, Jackie and Neumann, Inga D and Petersén, Åsa and Mathé, Aleksander A},
  issn         = {0969-9961},
  language     = {eng},
  pages        = {375--380},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Increased levels of cocaine and amphetamine regulated transcript in two animal models of depression and anxiety.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2009.02.010},
  volume       = {34},
  year         = {2009},
}