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How to assess transport in animals?

Rippe, Bengt LU (2009) 12th Congress of the International-Society-for-Peritoneal-Dialysis In Peritoneal Dialysis International 29(Suppl. 2). p.32-35
Abstract
The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different... (More)
The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different species. Although animal models only partly mimic human peritoneal dialysis, they are valuable tools for understanding the basic physiology and biology of peritoneal dialysis. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Capillary permeability, rat, aquaporin-1, transcytosis, mouse
in
Peritoneal Dialysis International
volume
29
issue
Suppl. 2
pages
32 - 35
publisher
Multimed Inc.
conference name
12th Congress of the International-Society-for-Peritoneal-Dialysis
external identifiers
  • wos:000263937100005
  • pmid:19270227
  • scopus:67449094663
ISSN
1718-4304
language
English
LU publication?
yes
id
7cc9523b-e3a7-4e40-a79e-7c77456f219a (old id 1370650)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19270227?dopt=Abstract
date added to LUP
2009-06-03 13:02:48
date last changed
2017-02-12 04:34:07
@article{7cc9523b-e3a7-4e40-a79e-7c77456f219a,
  abstract     = {The general principles for assessing solute and fluid transport across the peritoneum in animal models are not different from those in human studies. Animal models allow for extensive standardization of experimental conditions and also for sampling of peritoneal tissues for analysis. The present review will focus on (1) the scaling issue between various species, (2) how to measure intraperitoneal volume in animal models, (3) the impact of an indwelling catheter, (4) the difference between acute and chronic experiments, and (5) the particular problems associated with transport measurements in mice. If done correctly and after proper scaling, mass transfer area coefficients and clearance measurements show marked similarity among different species. Although animal models only partly mimic human peritoneal dialysis, they are valuable tools for understanding the basic physiology and biology of peritoneal dialysis.},
  author       = {Rippe, Bengt},
  issn         = {1718-4304},
  keyword      = {Capillary permeability,rat,aquaporin-1,transcytosis,mouse},
  language     = {eng},
  number       = {Suppl. 2},
  pages        = {32--35},
  publisher    = {Multimed Inc.},
  series       = {Peritoneal Dialysis International},
  title        = {How to assess transport in animals?},
  volume       = {29},
  year         = {2009},
}