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In vivo photosensitizer tomography inside the human prostate

Axelsson, Johan LU ; Swartling, Johannes LU and Andersson-Engels, Stefan LU (2009) In Optics Letters 34(3). p.232-234
Abstract
Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human... (More)
Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human prostate. (C) 2009 Optical Society of America (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Letters
volume
34
issue
3
pages
232 - 234
publisher
Optical Society of America
external identifiers
  • wos:000263755800003
  • scopus:59249107778
ISSN
0146-9592
language
English
LU publication?
yes
id
38a5fba1-6092-4f12-84fc-6c74b7784716 (old id 1370974)
date added to LUP
2009-05-08 14:38:06
date last changed
2017-10-08 03:58:07
@article{38a5fba1-6092-4f12-84fc-6c74b7784716,
  abstract     = {Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human prostate. (C) 2009 Optical Society of America},
  author       = {Axelsson, Johan and Swartling, Johannes and Andersson-Engels, Stefan},
  issn         = {0146-9592},
  language     = {eng},
  number       = {3},
  pages        = {232--234},
  publisher    = {Optical Society of America},
  series       = {Optics Letters},
  title        = {In vivo photosensitizer tomography inside the human prostate},
  volume       = {34},
  year         = {2009},
}