In vivo photosensitizer tomography inside the human prostate
(2009) In Optics Letters 34(3). p.232-234- Abstract
- Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human... (More)
- Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human prostate. (C) 2009 Optical Society of America (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1370974
- author
- Axelsson, Johan LU ; Swartling, Johannes LU and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Optics Letters
- volume
- 34
- issue
- 3
- pages
- 232 - 234
- publisher
- Optical Society of America
- external identifiers
-
- wos:000263755800003
- scopus:59249107778
- ISSN
- 0146-9592
- language
- English
- LU publication?
- yes
- id
- 38a5fba1-6092-4f12-84fc-6c74b7784716 (old id 1370974)
- date added to LUP
- 2016-04-01 14:02:41
- date last changed
- 2022-01-27 22:33:31
@article{38a5fba1-6092-4f12-84fc-6c74b7784716,
abstract = {{Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human prostate. (C) 2009 Optical Society of America}},
author = {{Axelsson, Johan and Swartling, Johannes and Andersson-Engels, Stefan}},
issn = {{0146-9592}},
language = {{eng}},
number = {{3}},
pages = {{232--234}},
publisher = {{Optical Society of America}},
series = {{Optics Letters}},
title = {{In vivo photosensitizer tomography inside the human prostate}},
url = {{https://lup.lub.lu.se/search/files/3741489/2366217.pdf}},
volume = {{34}},
year = {{2009}},
}