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Immune responsiveness in adult blue tits: heritability and effects of nutritional status during ontogeny

Råberg, Lars LU ; Stjernman, Martin LU and Hasselquist, Dennis LU (2003) In Oecologia 136(3). p.360-364
Abstract
What is the relative contribution of genetic and various environmental factors to variation in the ability to mount an immune response? We measured antibody responsiveness to diphtheria-tetanus vaccine during the winter in free-ranging blue tits with a known nestling history to investigate (1) if nutritional status during the nestling stage has persistent effects on an individual's immune defence and (2) if immune responsiveness is heritable. There was no correlation between nutritional status during the nestling phase (measured as size-corrected body mass day 14 post-hatch) and antibody responsiveness as an adult. On the other hand, the heritability of responsiveness to diphtheria and tetanus, as estimated by parent-offspring regression,... (More)
What is the relative contribution of genetic and various environmental factors to variation in the ability to mount an immune response? We measured antibody responsiveness to diphtheria-tetanus vaccine during the winter in free-ranging blue tits with a known nestling history to investigate (1) if nutritional status during the nestling stage has persistent effects on an individual's immune defence and (2) if immune responsiveness is heritable. There was no correlation between nutritional status during the nestling phase (measured as size-corrected body mass day 14 post-hatch) and antibody responsiveness as an adult. On the other hand, the heritability of responsiveness to diphtheria and tetanus, as estimated by parent-offspring regression, was 0.21+/-0.51 and 1.21+/-0.40 SE, respectively. Thus, while there was little evidence that natural variation in antibody responsiveness to these antigens reflected nutritional conditions during early life, responsiveness to at least one of the antigens (tetanus) had a strong genetic component. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Oecologia
volume
136
issue
3
pages
360 - 364
publisher
Springer
external identifiers
  • pmid:12783297
  • wos:000184756000004
  • scopus:0041695558
ISSN
1432-1939
DOI
language
English
LU publication?
yes
id
ae3011b9-4ef6-4f55-a233-ada050dda6c4 (old id 137194)
date added to LUP
2007-06-25 12:47:19
date last changed
2018-05-29 10:13:07
@article{ae3011b9-4ef6-4f55-a233-ada050dda6c4,
  abstract     = {What is the relative contribution of genetic and various environmental factors to variation in the ability to mount an immune response? We measured antibody responsiveness to diphtheria-tetanus vaccine during the winter in free-ranging blue tits with a known nestling history to investigate (1) if nutritional status during the nestling stage has persistent effects on an individual's immune defence and (2) if immune responsiveness is heritable. There was no correlation between nutritional status during the nestling phase (measured as size-corrected body mass day 14 post-hatch) and antibody responsiveness as an adult. On the other hand, the heritability of responsiveness to diphtheria and tetanus, as estimated by parent-offspring regression, was 0.21+/-0.51 and 1.21+/-0.40 SE, respectively. Thus, while there was little evidence that natural variation in antibody responsiveness to these antigens reflected nutritional conditions during early life, responsiveness to at least one of the antigens (tetanus) had a strong genetic component.},
  author       = {Råberg, Lars and Stjernman, Martin and Hasselquist, Dennis},
  issn         = {1432-1939},
  language     = {eng},
  number       = {3},
  pages        = {360--364},
  publisher    = {Springer},
  series       = {Oecologia},
  title        = {Immune responsiveness in adult blue tits: heritability and effects of nutritional status during ontogeny},
  url          = {http://dx.doi.org/},
  volume       = {136},
  year         = {2003},
}