Advanced

Non-coding RNAs revealed during identification of genes involved in chicken immune responses

Ahanda, Marie-Laure Endale; Ruby, Thomas; Wittzell, Hayenkan LU ; Bed'Hom, Bertrand; Chausse, Anne-Marie; Morin, Veronique; Oudin, Anne; Chevalier, Catherine; Young, John R. and Zoorob, Rima (2009) In Immunogenetics 61(1). p.55-70
Abstract
Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their... (More)
Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Non-coding RNAs, Microarray, Immune response, Chicken
in
Immunogenetics
volume
61
issue
1
pages
55 - 70
publisher
Springer
external identifiers
  • wos:000263060800005
  • scopus:59449084786
ISSN
1432-1211
DOI
10.1007/s00251-008-0337-8
language
English
LU publication?
yes
id
cbbba9ba-06a0-4d45-b59e-cd2982decc9a (old id 1374985)
date added to LUP
2009-05-08 15:42:55
date last changed
2017-12-10 04:02:14
@article{cbbba9ba-06a0-4d45-b59e-cd2982decc9a,
  abstract     = {Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.},
  author       = {Ahanda, Marie-Laure Endale and Ruby, Thomas and Wittzell, Hayenkan and Bed'Hom, Bertrand and Chausse, Anne-Marie and Morin, Veronique and Oudin, Anne and Chevalier, Catherine and Young, John R. and Zoorob, Rima},
  issn         = {1432-1211},
  keyword      = {Non-coding RNAs,Microarray,Immune response,Chicken},
  language     = {eng},
  number       = {1},
  pages        = {55--70},
  publisher    = {Springer},
  series       = {Immunogenetics},
  title        = {Non-coding RNAs revealed during identification of genes involved in chicken immune responses},
  url          = {http://dx.doi.org/10.1007/s00251-008-0337-8},
  volume       = {61},
  year         = {2009},
}