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Non-coding RNAs revealed during identification of genes involved in chicken immune responses

Ahanda, Marie-Laure Endale ; Ruby, Thomas ; Wittzell, Hayenkan LU ; Bed'Hom, Bertrand ; Chausse, Anne-Marie ; Morin, Veronique ; Oudin, Anne ; Chevalier, Catherine ; Young, John R. and Zoorob, Rima (2009) In Immunogenetics 61(1). p.55-70
Abstract
Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their... (More)
Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Non-coding RNAs, Microarray, Immune response, Chicken
in
Immunogenetics
volume
61
issue
1
pages
55 - 70
publisher
Springer
external identifiers
  • wos:000263060800005
  • scopus:59449084786
ISSN
1432-1211
DOI
10.1007/s00251-008-0337-8
language
English
LU publication?
yes
id
cbbba9ba-06a0-4d45-b59e-cd2982decc9a (old id 1374985)
date added to LUP
2016-04-01 13:16:37
date last changed
2022-01-27 18:18:45
@article{cbbba9ba-06a0-4d45-b59e-cd2982decc9a,
  abstract     = {{Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA sequences from immunologically active tissues with the aim of discovering chicken genes involved in immune mechanisms, and we decided to explore the non-coding component of these immune-related libraries. After finding known non-coding RNAs (miRNA, snRNA, snoRNA), we identified new putative mRNA-like non-coding RNAs. We characterised their expression profiles in immune-related samples. Some of them showed changes in expression following viral infections. As they exhibit patterns of expression that parallel the behaviour of protein-coding RNAs in immune tissues, our study suggests that they could play an active role in the immune response.}},
  author       = {{Ahanda, Marie-Laure Endale and Ruby, Thomas and Wittzell, Hayenkan and Bed'Hom, Bertrand and Chausse, Anne-Marie and Morin, Veronique and Oudin, Anne and Chevalier, Catherine and Young, John R. and Zoorob, Rima}},
  issn         = {{1432-1211}},
  keywords     = {{Non-coding RNAs; Microarray; Immune response; Chicken}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{55--70}},
  publisher    = {{Springer}},
  series       = {{Immunogenetics}},
  title        = {{Non-coding RNAs revealed during identification of genes involved in chicken immune responses}},
  url          = {{http://dx.doi.org/10.1007/s00251-008-0337-8}},
  doi          = {{10.1007/s00251-008-0337-8}},
  volume       = {{61}},
  year         = {{2009}},
}