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Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis

Cervin, Anders LU ; Wallwork, Ben ; Mackay-Sim, Alan ; Coman, William B. and Greiff, Lennart LU (2009) In Clinical Physiology and Functional Imaging 29(2). p.136-142
Abstract
Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 mu g ml(-1)) were carried out prior to and late into the treatment period. Histamine was included as a tool to produce plasma exudation, a process known to move free cellular products from the mucosal tissue into the airway lumen thereby enriching nasal surface liquids with such products. Interleukin-8 (IL-8), myeloperoxidase (MPO), eosinophil cationic protein (ECP), alpha(2)-macroglobulin and fucose were monitored as... (More)
Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 mu g ml(-1)) were carried out prior to and late into the treatment period. Histamine was included as a tool to produce plasma exudation, a process known to move free cellular products from the mucosal tissue into the airway lumen thereby enriching nasal surface liquids with such products. Interleukin-8 (IL-8), myeloperoxidase (MPO), eosinophil cationic protein (ECP), alpha(2)-macroglobulin and fucose were monitored as indices of pro-inflammatory cytokine production, neutrophil and eosinophil granulocyte activities, plasma exudation and mucinous secretion, respectively. Clarithromycin reduced the lavage fluid levels of IL-8 at the low-dose histamine observation (P < 0.001). There was a trend towards reduced MPO by the treatment, whereas ECP was significantly reduced at the low-dose histamine observation (P < 0.05). alpha(2)-Macroglobulin was reduced by clarithromycin (saline lavages) (P = 0.05), whereas fucose was unaffected. The exudative responsiveness to high-dose histamine was significantly reduced by the treatment (P < 0.05). Furthermore, significantly lower levels of fucose were observed at the low-dose histamine observation (P < 0.01). We conclude that long-term clarithromycin treatment likely exerts an anti-inflammatory effect in CRS. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
myeloperoxidase, alpha(2)-macroglobulin, interleukin-8, fucose, chronic rhinosinusitis, eosinophil cationic protein
in
Clinical Physiology and Functional Imaging
volume
29
issue
2
pages
136 - 142
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000263243600008
  • scopus:60149093233
  • pmid:19076731
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2008.00848.x
language
English
LU publication?
yes
id
366b85d7-cccf-4c9a-ad03-9a01a52d3abf (old id 1375044)
date added to LUP
2016-04-01 12:22:49
date last changed
2021-08-18 02:42:28
@article{366b85d7-cccf-4c9a-ad03-9a01a52d3abf,
  abstract     = {Macrolides can be clinically effective in chronic rhinosinusitis (CRS). However, little is known about how these drugs affect pathophysiological features of CRS in vivo. In the present study, patients with CRS were subjected to long-term treatment with clarithromycin. Nasal lavages with and without histamine (40 and 400 mu g ml(-1)) were carried out prior to and late into the treatment period. Histamine was included as a tool to produce plasma exudation, a process known to move free cellular products from the mucosal tissue into the airway lumen thereby enriching nasal surface liquids with such products. Interleukin-8 (IL-8), myeloperoxidase (MPO), eosinophil cationic protein (ECP), alpha(2)-macroglobulin and fucose were monitored as indices of pro-inflammatory cytokine production, neutrophil and eosinophil granulocyte activities, plasma exudation and mucinous secretion, respectively. Clarithromycin reduced the lavage fluid levels of IL-8 at the low-dose histamine observation (P &lt; 0.001). There was a trend towards reduced MPO by the treatment, whereas ECP was significantly reduced at the low-dose histamine observation (P &lt; 0.05). alpha(2)-Macroglobulin was reduced by clarithromycin (saline lavages) (P = 0.05), whereas fucose was unaffected. The exudative responsiveness to high-dose histamine was significantly reduced by the treatment (P &lt; 0.05). Furthermore, significantly lower levels of fucose were observed at the low-dose histamine observation (P &lt; 0.01). We conclude that long-term clarithromycin treatment likely exerts an anti-inflammatory effect in CRS.},
  author       = {Cervin, Anders and Wallwork, Ben and Mackay-Sim, Alan and Coman, William B. and Greiff, Lennart},
  issn         = {1475-0961},
  language     = {eng},
  number       = {2},
  pages        = {136--142},
  publisher    = {John Wiley & Sons Inc.},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2008.00848.x},
  doi          = {10.1111/j.1475-097X.2008.00848.x},
  volume       = {29},
  year         = {2009},
}