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Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?

Ngampasutadol, Jutamas; Tran, Connie; Gulati, Sunita; Blom, Anna LU ; Jerse, Ann E.; Ram, Sanjay and Rice, Peter A. (2008) In Vaccine 26. p.62-66
Abstract
Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind complement clown-regulatory proteins, C4b-binding protein (C4BP) and factor H (M), to evade killing by human complement. In addition, sialylation of gonococcal lipooligosaccharide (LOS) also enables N. gonorrhoeae to bind fH. Strains of N. gonorrhoeae that resist killing by human serum complement are killed by serum from rodent, lagomorph and primate species, which cannot be readily infected experimentally with this organism and whose C4BP and/or fH molecules do not bind to N. gonorrhoeae.... (More)
Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind complement clown-regulatory proteins, C4b-binding protein (C4BP) and factor H (M), to evade killing by human complement. In addition, sialylation of gonococcal lipooligosaccharide (LOS) also enables N. gonorrhoeae to bind fH. Strains of N. gonorrhoeae that resist killing by human serum complement are killed by serum from rodent, lagomorph and primate species, which cannot be readily infected experimentally with this organism and whose C4BP and/or fH molecules do not bind to N. gonorrhoeae. Serum resistance of gonococci is restored in these sera by human C4BP and/or fH Direct binding specificity of human and chimpanzee C4BP and human fH to gonococci may explain, in part, species-specific restriction of natural gonococcal infection and address why Por1B, but not Por1A containing gonococcal strains, have been successful in experimental chimpanzee infection. Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates. (C) 2008 Elsevier Ltd. All rights reserved. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
and factor H, C4b-binding protein, Species-specific infection, Gonorrhea, Complement
in
Vaccine
volume
26
pages
62 - 66
publisher
Elsevier
external identifiers
  • wos:000263005500012
  • scopus:57649177372
ISSN
1873-2518
DOI
10.1016/j.vaccine.2008.11.051
language
English
LU publication?
yes
id
939bb548-aaac-4ebc-8ddf-c49edbe04aee (old id 1375637)
date added to LUP
2009-05-08 16:48:13
date last changed
2017-08-20 03:45:57
@article{939bb548-aaac-4ebc-8ddf-c49edbe04aee,
  abstract     = {Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind complement clown-regulatory proteins, C4b-binding protein (C4BP) and factor H (M), to evade killing by human complement. In addition, sialylation of gonococcal lipooligosaccharide (LOS) also enables N. gonorrhoeae to bind fH. Strains of N. gonorrhoeae that resist killing by human serum complement are killed by serum from rodent, lagomorph and primate species, which cannot be readily infected experimentally with this organism and whose C4BP and/or fH molecules do not bind to N. gonorrhoeae. Serum resistance of gonococci is restored in these sera by human C4BP and/or fH Direct binding specificity of human and chimpanzee C4BP and human fH to gonococci may explain, in part, species-specific restriction of natural gonococcal infection and address why Por1B, but not Por1A containing gonococcal strains, have been successful in experimental chimpanzee infection. Our findings may help to improve animal models for gonorrhea while also having implications in the choice of complement sources to evaluate neisserial vaccine candidates. (C) 2008 Elsevier Ltd. All rights reserved.},
  author       = {Ngampasutadol, Jutamas and Tran, Connie and Gulati, Sunita and Blom, Anna and Jerse, Ann E. and Ram, Sanjay and Rice, Peter A.},
  issn         = {1873-2518},
  keyword      = {and factor H,C4b-binding protein,Species-specific infection,Gonorrhea,Complement},
  language     = {eng},
  pages        = {62--66},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Species-specificity of Neisseria gonorrhoeae infection: Do human complement regulators contribute?},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2008.11.051},
  volume       = {26},
  year         = {2008},
}