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Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in 0-35-Year Age Group in Sweden

Sanjeevi, Carani B.; Sedimbi, Saikiran K; Landin-Olsson, Mona LU ; Kockum, Ingrid and Lernmark, Åke LU (2008) 9th International Congress of the Immunology-of-Diabeties-Society/American-Diabeties-Association-Research Symposium In Immunology of Diabetes V: From Bench to Bedside 1150. p.106-111
Abstract
HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799 consecutively diagnosed T1D patients and 585 age-, sex-, and geography-matched healthy controls in the age group 0-35 years. HLA typing for high-risk haplotypes was previously performed using PCR-SSOP and RFLP The results showed that HLA DR3-DR4 gave an odds ratio of 8.14 for the whole of Sweden. However, when the study group was divided into six... (More)
HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799 consecutively diagnosed T1D patients and 585 age-, sex-, and geography-matched healthy controls in the age group 0-35 years. HLA typing for high-risk haplotypes was previously performed using PCR-SSOP and RFLP The results showed that HLA DR3-DR4 gave an odds ratio of 8.14 for the whole of Sweden. However, when the study group was divided into six geographical regions, subjects from Stockholm had the highest OR, followed by those from Lund, Linkoping, Gothenburg, Umea, and Uppsala. Absolute protection was conferred by the presence of DQ6 in subjects from the Linkoping region, but varied in the other regions. The frequency of DR3 and DQ2, DR4 and DQ8, DR15, and DQ6 in patients showed high linkage for each region, but were different between regions. In conclusion: The risk conferred by high-risk HLA varies in different regions for a homogenous population in Sweden. The results highlight the important role played by the various environmental factors in the precipitation of T1D. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
HLA-DR and DQ, type 1 diabetes, environmental factors, susceptibility, genetic
in
Immunology of Diabetes V: From Bench to Bedside
volume
1150
pages
106 - 111
publisher
Wiley-Blackwell
conference name
9th International Congress of the Immunology-of-Diabeties-Society/American-Diabeties-Association-Research Symposium
external identifiers
  • wos:000262400400018
  • scopus:57749188430
ISSN
0077-8923
ISBN
978-1-57331-733-7
DOI
10.1196/annals.1447.061
language
English
LU publication?
yes
id
0c62178f-6edc-4d4a-bc6a-c0917bb219a3 (old id 1376016)
date added to LUP
2009-04-17 10:04:04
date last changed
2017-01-01 05:58:01
@inproceedings{0c62178f-6edc-4d4a-bc6a-c0917bb219a3,
  abstract     = {HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799 consecutively diagnosed T1D patients and 585 age-, sex-, and geography-matched healthy controls in the age group 0-35 years. HLA typing for high-risk haplotypes was previously performed using PCR-SSOP and RFLP The results showed that HLA DR3-DR4 gave an odds ratio of 8.14 for the whole of Sweden. However, when the study group was divided into six geographical regions, subjects from Stockholm had the highest OR, followed by those from Lund, Linkoping, Gothenburg, Umea, and Uppsala. Absolute protection was conferred by the presence of DQ6 in subjects from the Linkoping region, but varied in the other regions. The frequency of DR3 and DQ2, DR4 and DQ8, DR15, and DQ6 in patients showed high linkage for each region, but were different between regions. In conclusion: The risk conferred by high-risk HLA varies in different regions for a homogenous population in Sweden. The results highlight the important role played by the various environmental factors in the precipitation of T1D.},
  author       = {Sanjeevi, Carani B. and Sedimbi, Saikiran K and Landin-Olsson, Mona and Kockum, Ingrid and Lernmark, Åke},
  booktitle    = {Immunology of Diabetes V: From Bench to Bedside},
  isbn         = {978-1-57331-733-7},
  issn         = {0077-8923},
  keyword      = {HLA-DR and DQ,type 1 diabetes,environmental factors,susceptibility,genetic},
  language     = {eng},
  pages        = {106--111},
  publisher    = {Wiley-Blackwell},
  title        = {Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in 0-35-Year Age Group in Sweden},
  url          = {http://dx.doi.org/10.1196/annals.1447.061},
  volume       = {1150},
  year         = {2008},
}